Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 4th European Chemistry Congress Barcelona, Spain.

Day 1 :

  • Advancements of Organic Chemistry
    Inorganic Chemistry
    Analytical Chemistry
    Green Chemistry: Green chemical principles
    Medical Biochemistry
    Physical Chemistry
Biography:

Julissa was born in San Juan, Puerto Rico. After participated in national and international scientific fairs at secondary level she decided to study Chemistry in University of Puerto Rico-Rio Piedras campus where she obtained a BS degree. Currently she is a Ph.D. candidate in the area of Inorganic Chemistry and work with surface modification of zirconium phosphate nanoparticles for drug delivery system applications. In addition, she is member of the Caribbean Brigade of the Solar Army during the last five years as part of the Center for Chemical Innovation in Solar Fuels (CCI Solar) an NSF Center for Innovation in Solar Fuels.

Abstract:

Surface modification of doxorubicin anticancer drug (DOX) intercalated zirconium phosphate (ZrP) nanoparticles (DOX@ZrP) is proposed to improve the potential of this drug delivery system for cancer therapy. The surface of DOX@ZrP nanoparticles was modified with an amorphous layer of Zr(IV) followed by modification with monomethyl-polyethylene glycol-monophosphate (m-PEG-PO3) to increase the DOX@ZrP biocompatibility. 31P{1H}MAS NMR data shows a new peak at -26 ppm corresponding to the PO43- groups coordinated with Zr(IV) on the surface. m-PEG-PO3/Zr(IV)/DOX@ZrP spectra shows no additional resonance centered at d of -22.6 ppm generated by proton-phosphorous cross polarization indicating no partial PEG intercalation in the interlaminar space. Simulated body fluid (SBF) was used to determine the in vitro release of DOX from DOX@ZrP, Zr(IV)/DOX@ZrP, and m-PEG-PO3/ Zr(IV)/DOX@ZrP.  MTS cell viability assay reveal that m-PEG-PO3/ Zr(IV)/DOX@ZrP exhibited a 20% increase in the toxicity comparing with free DOX when PC3 cells are exposed for 48 h.  m-PEG-PO3 polymer coating of DOX@ZrP nanoparticles promise to have a strong impact on the targeting, distribution and degradation of the nanoparticles under physiological environment that should result in a more efficient chemotherapy agent than free doxorubicin.

Biography:

I am currently completing PhD Chemistry Study Program at Andalas University in Padang, Indonesia. I lecturer  Department of Chemistry, Faculty of Mathematics and Natural Sciences, Andalas University Padang, 25163 Indonesia. I have published more than 13 papers in reputed journals.

 

Abstract:

Adsorptive stripping voltammetry is one of the stripping voltammetry method that is widely used in the analysis of heavy metals because it has good sensitivity. metals with very small concentrations can be analyzed. The purpose of this study was to obtain the optimum condition of the Zn metal ions simultaneously. To achieve these objectives. required an optimization technique of analytical procedures by using Response Surface Methodology.with Central Composite Design (CCD). The research design was used in this study is a CCD with 4 variables. 3 level and 31 a combination of treatments. The first step of 2k factorial design optimization are: to give the highest level of code values ​​(+1). the lowest level (-1) and code (0) as the center point. Programs that will be used for statistical data processing. namely Mini Tab using RSM. Based on data analysis with response surface method. the obtained optimum conditions for the determination of zinc is: calcon concentration of 0.71 mmol/L; pH = 7.18; accumulation potential -0.56 V and the accumulation time 62.16 s. From the results obtained optimum conditions RSD  of 2.5% with a recovery of 98.01%. respectively. Limit of Detection (LOD) for Zn(II) was 1.21 (µg /L). RSM has been successfully applied to the determination of Zn in environmental samples fast and effectively.

Biography:

Manmohan Lal Satnami is an Assistant Professor at the School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur (C.G.), India. He is recipient of TWAS-CNPq postdoctoral award (2006–07). He is awarded with UGC ResearchAward 2016-18. He has also been awarded the title of Young Scientist by the Department of Science and Technology (DST), New Delhi under the Fast Track Research Project Scheme in the year-2012. His research Interest includes applications of metal nanoparticles and quantum dot nanomaterial, catalysis, surface chemistry, and micellar catalysis.

Abstract:

Quantitative detection of glucose is an important issue in food industry, various biotechnological processes and medication of metabolic disorders. Herein, we have reported a detectionmethod based on Mn2+-doped-CdTe/ZnS modified nanosensor for rapid and sensitive detection of glucose levels in human biological fluids i.e. blood and urine. In this strategy Mn2+-doped CdTe/ZnS quantum dots (QDs) were designed for the direct measurement of glucose. The fluorescence (FL) of Mn2+-doped CdTe/ZnS QDs was sensitive to hydrogen peroxide (H2O2). The catalytic oxidation of glucose by glucose oxidase (GOx) produces H2O2 that extensively quenched the FL of QDs. Experimental results showed that the decrease of the QDs FL was
proportional to the concentration of glucose within the range of 0.1 nM to 10 μM with the detection limit of 0.1nM under the optimized experimental conditions. Glucose in blood and urine samples was effectively detected by this strategy. The comparison with commercialized glucose meter indicated that this proposed glucose assay system is not only simple, sensitive, but also reliable and suitable for practical application. The high sensitivity, versatility, portability, high-throughput and low cost of this glucose sensor implied its potential in point-of-care clinical diagnosis of diabetes and other fields.

Biography:

Hardy Castada is a post-doctoral food scientist and analytical chemist with research interest in the fundamental and applied volatile compound analysis using SIFT-MS. He studies physico-chemical changes and behavior of volatile, semi-volatile, aroma and flavor volatiles in various matrixes and systems.

Abstract:

Volatile 4-alkyl-branched fatty acids and 3-methylindole are characteristic flavor compounds associated with lamb. The partitioning behavior of these volatile organic compounds (VOCs) between the gas and condensed phase is important for their effective characterization especially during high throughput screening and quantitative analysis.

Selected ion flow tube-mass spectrometry (SIFT-MS) was used for the headspace concentration analysis of the compounds associated with lamb flavor. Standard solutions of 4-ethyloctanoic acid, 4-methyloctanoic acid, 4-ethylnonanoic acid and 3-methylindole were prepared in an oil-based matrix, equilibrated for an hour at 4 different temperatures (80, 100, 110 and 125oC), prior to headspace sampling and quantification. Further linear regression analyses and calculations of Henry’s law constants were carried out at each specified equilibration temperature.

The Henry’s law constants of the lamb flavor compounds were calculated with a high degree of confidence (p<0.05) based on direct proportionality with a very good fit of linearity (R2>0.99) between the headspace and solution concentration of the standard solutions. The detected headspace concentrations increased with elevated equilibration temperature resulting to increased volatility of the compounds. Therefore, the calculated temperature-dependent Henry’s law constants for these volatile compounds decreased with increasing temperature.

We have established the temperature-dependent Henry’s law constants for the volatiles 4-alkyl branched-chain fatty acids and 3-methylindole in air-oil matrixes. As the equilibration temperature is increased, volatility increases and Henry’s law constant decreases with increasing molecular weight. The partitioning behavior of the compounds is necessary for their high throughput characterization and approximation of their concentrations in situ.

Biography:

Don Coltart obtained his Master’s degree from the University of Manitoba under the supervision of Professor James L. Charlton, and he then joined the research group of Professor Derrick L. J. Clive at the University of Alberta where he obtained his Ph.D. His postdoctoral work was conducted at the Memorial Sloan-Kettering Cancer Center as an NSERC, AHFMR, and CRI Scholar under the supervision of Professor Samuel J. Danishefsky. Don began his independent career at Duke University in 2004 and moved to the University of Houston in 2012. His research group studies the development of methods for asymmetric carbon–carbon bond formation, the application of those methods to the total synthesis of structurally complex biologically active natural products, and the study of those compounds in biological systems.

Abstract:

The asymmetric α-alkylation of carbonyl compounds is a fundamental synthetic
transformation. Remarkably, despite its importance, there is no general way to conduct this transformation in a catalytic asymmetric fashion. The umpolung-based alkylation of ketones and aldehydes wherein an organometallic species adds to an electrophilic α-carbon through the intermediacy of a derived azo- or nitrosoalkene provides an appealing approach to effecting this transformation. Not only does such an approach allow for the incorporation of functionality that cannot be introduced using enolate chemistry, but it is also well suited to catalysis and adaptable for asymmetric induction. Given the wide range of structures available as organometallic reagents (e.g., 1°, 2°, 3° alkyl, aryl, vinyl, alkynyl, etc.), this approach to catalytic asymmetric α-alkylation is
also likely to prove broad in scope. Herein, we describe our recent efforts to exploit this mode of reactivity to provide a solution to the long-standing problem of developing a general, catalytic asymmetric approach to the α-alkylation of carbonyl compounds.

Biography:

Amit Adhikary obtained his PhD on molecular self-assembly of magnetic materials from Indian Institute of Science Education and Research Bhopal, India. After that he has completed his 1.5 years first postdoctoral studies on thermoelectric materials from Missouri University of Science and Technology, Rolla, MO,USA. Currently he is a national postdoc fellow in IACS, Kolkata, India where he is doing independent research for the devolopment of lanhanide based molecular magnet. He has published 22 papers in reputed journals.

Abstract:

A newly synthesized ternary sulfide composition, NaGaS2 (1) has remarkable ability to capture atmospheric water molecules. The absorption of water was verified by PXRD, TG analysis, FT-IR and XPS studies. The process of water absorption leads to stable distinct material NaGaS2• ~H2O (2), the structure of which is different from original crystal structure of anhydrous phase. Interestingly the transformed structure 2 can go back to original structure 1 by simple heating under inert atmosphere, unveiling reversibility of structural transformation. Single crystal XRD study shows adamantane like Ga4S10 super tetrahedral units form the fundamental building unit of the structure and further corner sharing between these units forms the [GaS2]layers. The charge-balancing Na ions are present in between the layers. Moreover, structural transformation also effects the physical properties as initial compound 1 possesses Na+ ion conductivity of 1.49 x 10-7 S cm-1 at 22°C with Ea of 0.14 eV whereas 2 displays ion conductivity of 1.85 x 10-8 S cm-1 at 23°C with Ea of 0.19 eV. Experimental DRS study shows an optical band gap of 2.40 eV which closely corroborates with the theoretical band gap of 2.35 eV obtained by DFT-based band structure calculation. Vapor sorption studies indicate exclusively adsorption of water over MeOH, EtOH and CH3CN, revealing ‘Single Molecule Trap’1 behavior with maximum water uptake of 372 cm3 g-1 at P/P0 = 0.9.2 DFT calculations3 reveal that exergonic hydration reaction takes place outlined as NaGaS2 + H2O → NaGaS2•H2O with the energy release ΔE of -73.9 kJ.mol-1.

Biography:

Ismael Zamora,  Lead Molecular Design S.L, Spain

Abstract:

The structure elucidation based on Mass Spectra (MS) data of unknown substances is an unresolved problem that affects many different fields of application. The recent overview of software available for structure elucidation of small molecules has shown the demand for efficient computational tool that will be able to perform structure elucidation of unknown small molecules and peptides. We developed an algorithm for De-Novo fragment analysis based on MS data that proposes a set of scored and ranked structures that are compatible with the MS and MSMS spectra.

Several different algorithms were developed depending on the initial set of fragments and the structure building processes. In addition, in all cases several scores for the final molecule ranking were computed. They were validated with small and middle databases (DB) with the eleven test set compounds. Similar results were obtained from any of the databases that contained the fragments of the expected compound.

We presented an algorithm for De-Novo fragment analysis based on only mass spectrometry (MS) data only that proposed a set of scored/ranked structures that was validated on different types of databases and showed good results as proof of concept.

Moreover, the solutions proposed by Mass Spectrometry were submitted to the prediction of NMR spectra in order to elucidate which of the prposed structures was compatible with the NMR spectra collected

Biography:

Grützmacher has completed his PhD at the University of Göttingen, Germany, and continued as a Post-doc at the University of Toulouse. Afterwards he obtained his habilitation from the University of Heidelberg before he was appointed as assistant professor at the University of Freiburg. He then moved to the ETH of Zürich where he holds a full professorship in inorganic chemistry. He has published more than 200 papers and filed about 20 patents. He has been in the advisory board of several general chemistry journals and is currently one of the curators of the Angewandte Chemie.

Abstract:

The development of efficient catalytic processes that mimics the enzymatic function of alcohol dehydrogenase is critical for using biomass alcohols for the production of H2 as chemical energy carrier and fine chemicals under waste-free conditions. Our own research efforts focus on dehydrogenative coupling reactions (DHC) which is an atom economic and efficient way to obtain carbonic acids, ester, and amides from alcohols. This approach can also be used to generate main group element bonds according to E-H + Y-H => E-Y + H2. We could develop successfully transition metal complexes with olefins as steering ligands and amido functions as cooperating ligands to efficiently promote the DHC of various substrates which range from renewable feedstock to silanes and amino boranes. Most of these reactions proceed with a very high turnover frequency and high chemoselectivity. Possible mechanisms will be discussed which inspired the development of an Organometallic Fuel Cell (OMFC), efficient catalysts for the conversion of methanol water mixtures into H2 and CO2, and efficient routes to main group element compounds as precursors to materials.

Biography:

Irina Beletskaya is a professor of chemistry at Moscow State University, the head of the Organoelement Chemistry laboratory. Her interests are focused on organometallic chemistry and transition metal catalysis applied to organic synthesis. She developed some of the first methods for carbon-carbon bond formation using palladium or nickel catalysts, and extended these reactions to work in aqueous media. Irina Beletskaya is a Full Member of the Russian Academy of Sciences, a former president of the Division of Organic Chemistry of IUPAC, and Editor-in-chief of the Russian Journal of Organic Chemistry. She is a recipient of many national and international awards, including the State Prize (2004) and the IUPAC Distinguished Women in Chemistry award (2013).

Abstract:

In this presentation two types of processes will be considered.

  1. Cross-coupling reactions of carbon-carbon and carbon-heteroatom bond formation (including the reactions of C-H activation)
  2. The addition of S-H, Se-H, P-H, H-H bonds to alkynes, alkenes and imines (including asymmetric Friedel-Crafts/Michael addition reactions).

Biography:



Irina Beletskaya is a professor of chemistry at Moscow State University, the head of the Organoelement Chemistry laboratory. Her interests are focused on organometallic chemistry and transition metal catalysis applied to organic synthesis. She developed some of the first methods for carbon-carbon bond formation using palladium or nickel catalysts, and extended these reactions to work in aqueous media. Irina Beletskaya is a Full Member of the Russian Academy of Sciences, a former president of the Division of Organic Chemistry of IUPAC, and Editor-in-chief of the Russian Journal of Organic Chemistry. She is a recipient of many national and international awards, including the State Prize (2004) and the IUPAC Distinguished Women in Chemistry award (2013).

Abstract:

In this presentation two types of processes will be considered.

  1. Cross-coupling reactions of carbon-carbon and carbon-heteroatom bond formation (including the reactions of C-H activation)
  2. The addition of S-H, Se-H, P-H, H-H bonds to alkynes, alkenes and imines (including asymmetric Friedel-Crafts/Michael addition reactions).

Biography:

Rocio Gamez-Montano was born in Michoacán, México in 1970. She got her PhD in 2001 under guidance of Professor Raymundo Cruz-Almanza in UNAM, CDMX, México. After a post-doctoral fellow in 2002 under guidance of Professor Jieping Zhu at Gif-Sur-Yvette, France, she was incorporated to University of Guanajuato, México since 2003, where is actually full-time Researcher-Professor (Class B). Her scientific interest includes the synthesis of heterocycles and poly-heterocycles via MCR, in vitro and in silico studies of biological properties, applications in optics, as well as study of reaction mechanisms.

Abstract:

Bis-heterocycles are structurally complex compounds having two linked, fused, merged or bound heterocyclic frameworks,1 which have attracted much attention of synthetic community due to their potential applications in agrochemistry, optics, material science, and medicinal chemistry.2 Moreover, 1,5-disubstituted-tetrazoles (1,5-DS-T’s) are known as resistant bioisosters of the cis-amide bond of peptides,3 which are present in numerous valuable drugs like the 3rd generation cephalosporin antibiotic Latamoxeb.4 Besides, 1,5-DS-T’s are suitable precursors of a plethora of MOF´s and chelating agents.5 Thus, according to our ongoing program to develop short and versatile Ugi-azide based methodologies toward a variety of methane-linked bis-heterocycles containing the 1,5-DS-T moiety, we herein show our most recent published results.

In 2013, we described the synthesis of azepino[4,5-b]indol-4-one-1,5-1H-tetrazoles in two steps: i) one pot (Ugi-azide/N-acylation/SN2), and ii) free radical mediated cyclization, as well as in silico studies as 5-Ht6R ligands using docking techniques (Figure 1a).6 In 2014, we reported the synthesis of 2,3,4,9-tetrahydro-b-carboline-1,5-1H-tetrazoles by a one pot Ugi-azide / Pictet-Spengler process (Figure 1b).7 In 2014, we reported the synthesis of chromen-4-ones-1,5-1H-tetrazoles via the Ugi-azide reaction and in vitro studies of antiparasitic properties against E. histolytica, G. lamblia, and T. vaginalis.8 Then, in 2015 we extended this work synthesizing some fluorinated analogs, which together with the previously synthesized bis-heterocycles were assayed in vitro against P. aeruginosa, S. aureus, S. schenckii, C. albicans, and C. tropicalis (Figure 1c).9 Finally, just recently in 2016, we reported the synthesis of novel 3-tetrazolyl-tetrazolo[1,5-a]quinolines via a novel one pot Ugi-azide / SNAr / ring-chain azido-tautomerization process (Figure 1d).10 As seen, the Ugi-azide reaction or its combination with further cyclization processes allows the rapid synthesis of a variety of methane-linked bis-heterocycles with potential application mainly in medicinal chemistry because 1,5-DS-T framework has been suitably combined with other heterocyclic systems, which are present in numerous bioactive products, even in drugs.

Figure 1

 

Biography:

Alexander O. Terentev was born in Moscow, in 1973. He received his M.S. in Chemistry of Biologically Active Compounds from D. Mendeleev University of Chemical Technology of Russia, Moscow. PhD degree (2000) and D.Sc. degree (2009) in Organic Chemistry in N.D. Zelinsky Institute of Organic Chemistry RAS. 2011 – Professor D. Mendeleev University of Chemical Technology of Russia. 2016 – Professor RAS. Head of laboratory in N.D. Zelinsky Institute of Organic Chemistry RAS, Head of laboratory in All-Russian Research Institute of Phytopathology. His interests are organic chemistry, medical and agricultural chemistry, chemical technology. He published 3 chapters in books, 90 research papers, and 24 patents.

Abstract:

Oxidative cross-dehydrogenative coupling methodology lies in the modern trend of organic chemistry. It eliminates necessity for installation of additional functional groups and affords direct coupling in one stage (via selective C-H activation) with limited amount of wastes, high atom- and step- economy.

Oxidative cross-dehydrogenative C-C coupling was studied in most detail; the C-N, C-P, and C-O cross-coupling reactions are less well developed. It is difficult to achieve high selectivity in the cross-dehydrogenative C-O coupling because the starting compounds are prone to side oxidation and fragmentation reactions giving, for example, alcohols and carbonyl compounds. This gives rise to a problem of searching for oxidizing agents and reaction conditions suitable for the cross-coupling of different types of substrates.

We discovered oxidative cross-dehydrogenative C-O coupling of 1,3-dicarbonyl compounds and their heteroanalogs with peroxides, oximes and hydroxyamides. The best results were obtained with the use of the widely available copper, iron, manganese or lanthanide salts as catalysts or oxidants.

In the case of oximes and hyroxyamides, apparently, the reaction proceeds via the radical mechanism, in which the oxidizing agent serves to generate O-centred radicals from oximes and hyroxyamides. The formation of O-centered radicals was confirmed by ESR spectroscopy.

Generally speaking, in this work we found a new approach to the solving of problem for selective oxidation of sp3 carbon atom.This work was supported by the Russian Science Foundation (Grant 14-23-00150).

Biography:

Vakhtang Barbakadze in 1978 and 1999 has completed his Ph.D and D.Sci. at the ages of 33 and 54 years from Zelinsky Instiute of Organic Chemistry, Moscow, Russia and Durmishidze Institute of Biochemistry and Biotechnology, Tbilisi, Georgia, respectively. 2006 up to date he is the head of laboratory of plant biopolymers at the Tbilisi State Medical University Institute of Pharmacochemistry. 1996 and 2002 he has been a visiting scientist at Utrecht University (faculty of pharmacy), The Netherlands, by University Scholarship and The Netherlands organization for scientific research (NWO) Scholarship Scientific Program, respectively. He has published more than 80 papers in reputed journals.

Abstract:

The 13C NMR experiments of water-soluble high-molecular preparations from different species of Boraginaceae family were carried out and simulated 13C NMR spectrum was calculated for 2-hydroxy-3-(3',4'-dihydroxyphenyl)-propionic acid residue (I) of the corresponding polyether using ACD/CNMR Version 1.1  program. Signal positions in the 13C NMR spectrum of this hypothetical structure (I) coincided satisfactory with the experimental values. According to 13C, 1H NMR, APT, 2D heteronuclear 1H/13C HSQC and 2D DOSY experiments the main structural element of these preparations was found to be a regularly substituted by 3,4-dihydroxyphenyl  and  carboxyl  groups polyoxyethylene backbone, namely poly[3-(3,4-dihydroxyphenyl)glyceric acid] (PDPGA) or poly[oxy-1-carboxy-2-(3,4-dihydroxyphenyl)ethylene]. The synthesis of racemic monomer of PDPGA 2,3-dihydroxy-3-(3,4-dihydroxyphenyl)propionic acid (DDPPA) and its enantiomers (+)-(2R,3S)-DDPPA and (–)-(2S,3R)-DDPPA was carried out via Sharpless asymmetric dihydroxylation  of  trans-caffeic acid derivatives using a potassium osmate catalyst and enantiocomplementary catalysts cinchona  alkaloid  derivatives  (DHQ)2-PHAL  and  (DHQD)2-PHAL as chiral auxiliaries. The opposite configuration of both enantiomers was confirmed by measurements of the optical rotation (+)/(–)-values and circular dichroism spectra. The determination of enantiomeric purity was performed by HPLC analysis. PDPGA and DDPPA  exerted  anti-cancer efficacy  in vitro  and  in vivo  against    human  prostate cancer (PCA) cells  via  targeting  androgen  receptor,  cell  cycle  arrest  and  apoptosis  without  any  toxicity, together  with  a strong  decrease  in  prostate  specific antigen  level in plasma. However, our  results  showed  that anticancer efficacy of  PDPGA  is more effective compared to its synthetic  monomer. Overall, this study identifies  PDPGA as a potent agent against PCA  without any toxicity, and  supports  its clinical application.

 

Biography:

Eric Pasquinet has completed his PhD from the University of Rouen. He has been working for more than 15 years at CEA on synthesis projects, mainly involving nitrogen heterocycles. He has published more than 25 papers and 12 patents.

Abstract:

The aza-Wittig reaction is a widely known and used reaction, which consists of the coupling between an iminophosphorane (obtained from the reaction of a trialkylphosphine on an azide) and an unsaturated carbonyl-type compound. In its intramolecular version, the aza-Wittig reaction gives access to many aza-heterocycles from 5- to 7-membered rings.In such processes, the use of N-electrophiles has never been reported. We investigated nitroso compounds as electrophiles to promote the formation of a N=N double bond. In particular, we found that aromatic iminophosphoranes (coming from the reaction between an aromatic azide and a trialkylphosphine) could cyclize onto an ortho benzylic nitroso moiety, leading to a 3H-indazole that isomerized into its more stable 1H analogue. This process can be operated one-pot, without isolation of the intermediate iminophosphorane. This means that, in a single operation starting from an aromatic azide, the targeted 1H-indazole is generated. Various aryl- and hetaryl azides were used to demonstrate the generality of the method, leading to 1H-indazoles, 1H-benzoindazoles and 1H-azaindazoles (scheme 1).

The reaction pathway will also be discussed. It involves a mechanism analogous to that reported for the aza-Wittig reaction. Therefore the key transformation of the process was given the name ‘diaza-Wittig’.

Biography:

Davide Motta is a PhD student at Cardiff, as part of CDT in Catalysis between the university of Bath, Bristol and Cardiff. He got master degree in Industrial Chemistry at University of Milan in 2014 and a master of research in Catalysis at Cardiff University in 2015.

Abstract:

Modern society relies on oil and hydrocarbon to satisfy its energy requirements. However the usage of oil is depleting the world resources and increase the emission of greenhouse gases, leading to grave consequences for the whole planet. In this optics the research for new cleaner and renewable energy sources is necessary more than needed, between this hydrogen has created a lot of interest as both fuel and energy carriers.

Hydrogen has an energy density three times higher than petroleum, 120 kJ g-1, that can be released with high efficiency using fuel cell systems combined with electrical engines. Moreover fuel cells are really clean energy systems that produce only water as by-product, in this way the level of pollutant and greenhouse gases in the atmosphere.

Main drawback for hydrogen application is the need to find an efficient and safe method of transportation. From this point of view chemical liquid storage system like hydrazine and formic acid are really promising platform for large scale application of fuel cell system. We used iridium-based catalysts to catalyse the decomposition of hydrous hydrazine into molecular hydrogen and nitrogen . The catalyst have been prepared using differents preparation methods like deposition-precipitation and sol-immobilisation, and bimetallic systems using other metals such as Fe and Ni.

Biography:

Ejidike Peter has completed his PhD from University of Fort Hare, South Africa and presently a postdoctoral candidate at University of Fort Hare, School of Science and Agriculture. He has published more than 8 papers in reputed journals; others under review, and has been serving as a reviewer to some journals. He is a member of the South African Chemical Institute (SACI) and International Union of Pure and Applied Chemistry (IUPAC).

Abstract:

The strategic design of biologically active molecules is a vigorous task and the variables affecting biological activity are diverse. Metal based antioxidants have gained recent attention for their ability to protect living organisms and cells from damage caused by oxidative stress or scavenge free radicals. In view of the growing interest in the development of new therapeutic agents and DNA probes for disease defence, we present ruthenium(III) complexes of three tetradentate Schiff bases with a N2O2 donor atoms set and formulated as: [RuCl(LA)(H2O)]; [RuCl(LB)(H2O)]; [RuCl(LC)(H2O)]. The spectra data showed that the ligands coordinate Ru ion through the azomethine nitrogen and enolic oxygen atoms. Electronic spectral measurements indicated an octahedral geometry for all the complexes. The antioxidant activities of the complexes were investigated through scavenging activity on DPPH and ABTS radicals. The obtained IC50 value of the DPPH activity for the [RuCl(LB)(H2O)] complex (IC50 = 1.58±0.50 µM) was higher than other Ru(III) compounds. The study revealed that the Ru(III) complexes exhibited strong scavenging activities against DPPH and moderate ABTS radicals. In addition, the anticancer studies of the complexes were also tested against human renal cancer cell (TK10), human melanoma cancer cell (UACC62) and human breast cancer cell (MCF7) using the SRB assay with moderate anticancer activity against the tested cell lines. [RuCl(LB)(H2O)] chelates exhibited higher bioactivities than [RuCl(LA)(H2O)] and [RuCl(LC)(H2O)] complexes. Nevertheless, antioxidant activities of the complexes showed moderate to strong free radical inhibitors for treating pathological damage associated with radical-generation leading to aging, degenerative diseases and cancer.

Biography:

Abstract:

Tenskinmetry is a conceptually innovative Tensiometric Versus Skin (TVS) pathway for non-invasive evaluation of surface energy phenomena closely related to the epidermal functional state. The TVS modeling: (i) exploits the structure-surface correlations which are characteristic of all systems; (ii) applies the principle of permutability of the tensiometric technique, according to which unknown solids can be characterized by their known surface characteristics, and vice versa; (iii) applies the contact angle method, with only water as reference liquid; (iv) is carried out by a suitable mobile tensiometer (tenskinmeter) directly in contact with the skin in a non-invasive way; (v) measures and correlates the surface free energy reflex induced by inter- and intra-molecular and particle forces acting on underlying epidermic layers; (vi) allows the epidermal hydration directly from the polar surface energy fraction.

Biography:

Denis Lutckii graduated St. Petersburg State Mining Institute (Technical University) on a specialty "Metallurgy of ferrous metals", qualification "engineer". In 2011, after graduate school, defended his thesis for the degree of candidate of technical sciences, specialty 05.16.02 "Metallurgy of ferrous, non-ferrous and rare metals", thesis - "Recovery and separation of lanthanides hydrometallurgical methods for complex processing of raw low-concentration" Working at the Department of General and Physical Chemistry since 2008

 

Abstract:

Various types of vegetable oil-based organic solvents (VOS), i.e. vegetable oils (corn, canola, sunflower and soybean oils) with and without extractant (pure oleic acid), were investigated into their potentiality as greener substitutes for the conventional petroleum-based organic solvents to extract REM from aqueous solutions [1, 2]. The pH-extraction isotherms of Ce (III) using various vegetable oils loaded with oleic acid were investigated and the percentage extraction of Ce (III) achieved by different types of VOS was determined. Vegetable oils without extractants showed a poor extractability for Ce (III). Vegetable oils loaded with oleic acid were found to be the most effective VOS for Ce (III) extraction and, thus, are potential greener substitutes for the conventional petroleum-based organic solvents.

It was shown that all vegetable oils investigated such as olive and sunflower, either with or without naphthenic acid exhibited a similar trend of extractability for Ce (III) from aqueous solutions. A sigmoid curve was obtained for all the pH-extraction isotherms of Ce (III) investigated with various types of vegetable oils loaded with 500 mM of naphthenic acid as VOS. The extraction was the lowest at pH of 4.0, but increased sharply from 4.7 to 5.5, and achieved its maximum from 5.5 to 6.0. Vegetable oils without extractants were poor VOS for Ce (III) wherein only about 10% of Ce (III) was extracted. Hence, vegetable oils functioned more as diluents than as additional extractants in Ce (III) extraction. Vegetable oils loaded with 500 mM naphthenic acid, however, were effective VOS where more than 90% of Ce (III) was extracted from aqueous solutions. Therefore, naphthenic acid functioned as an effective extractant in Ce (III) extraction by various types of VOS.

Figure. 1: Degree of extraction Ce (III) from the equilibrium pH of the aqueous phase in the extraction solution of oleic acid in o-xylene, paraffin, olive oil and sunflower.

Biography:

Eugenia Fagadar-Cosma has completed her PhD in 1997 at Polytechnical University of Timisoara. She is senior scientist, doctoral advisor and coordinator of Organic Chemistry –Porphyrin Programmes in Institute of Chemistry Timisoara of Romanian Academy. She has published more than 250 peer-reviewed full-papers,  93 papers in prestigious ISI journals, 8 books and 2 chapters in international volumes, 7 patents and has been serving as an editor to a special issue (Bentham). She was involved in managing of many FP6 , FP7 and national granted projects. She is reviewer of more than 20 ISI indexed Elsevier, Springer and ACS Journals.

Abstract:

Most synthetic porphyrins are hydrophobic π-conjugated  macrocycles and as a consequence organic building blocks for supramolecular chemistry, providing in this way the required optoelectronic and  morphological properties for a plethora of  novel sensors. Besides, porphyrins possess huge capacity for chemical modifications by peripheral substitution and by using them in hybrid combination with photonic, electronic and magnetic compounds. Wide band absorption hybrid materials were prepared from different A3B porhyrins  and cobalt, manganese and zinc metalloporphyrins and silver or gold nanoparticles with the purpose to develop optical and electrochemical detection of hydrogen peroxide or other compounds showing potential in early medical diagnosis. The synthesized materials were characterized by UV-vis, fluorescence, FT-IR, AFM, SEM TEM and CV. STEM investigation of the porphyrin-gold hybrids revealed some dendritic structures produced mainly by porphyrin H- and J-type helicoidal self-aggregation due to their interaction with gold nanoparticles. Layer-by-layer assembly of gold colloid nanoparticles and cobalt porphyrins on GC electrodes generated electroactive thin films capable to electrochemically detect minute quantities of H2O2 that are relevant for early diagnosis in medicine. The Co-porphyrin-gold hybrid was exposed to increased amounts of H2O2 and the changes of the absorption spectra were monitored by UV-vis spectroscopy, proving the same quality of sensing capacity.

Biography:

Samar Gewily has completed her Bsc of science in Chemistry and Ecology from Monash University, AUS. She worked for WWF-UAE in environmental education program, a leading organization in environmental education and conservationa work. She has published on Wadi Wurayah Nationl Park, UAE. Also participated in two research projects with Earth Watch, AUS. She has joined a UNESCO program for Young Ecologist in Ethiopia and UAE for Biosphere Reserves. Currently works as Expert in Chemistry at Dubai Police Forensic Laboratory, UAE. Presented a scientific paper at Hemaya 12th Annual Conference, Dubai, UAE in 2016, for Narcotics.

Abstract:

Illicit production of Captagon tablets has become widely spread in the Middle East recently. Around 5% of cases of seized drugs in Dubai in 2016 were Captagon. Originally Captagon is the trademark name of Fenethylline, however studies and chemical analysis of seized tablets has proven the absence of Fenethylline, rather it showed different combinations of Amphetamine, Caffeine and other compounds. In this study, total of 20 representative samples from different cases were analysed chemically using Gas Chromatography coupled with Mass Spectroscopy (GC-MS), and Micro X-Ray Fluorescence (µXRF) to determine organic and inorganic content. In addition, samples were physically characterised using 3D microscope. Based on results, comparisons were made between samples and linked to information on originality as a first step towards Captagon Profiling.

Biography:

Hugo Romero Bonilla  has completed the Master's Program in chemistry at the Pontificia Catholic University of Valparaiso, Chile. Currently (2016) he completed the PhD program in environmental science in San Marcos University, Perú. He works as a researcher and professor at the Faculty of Chemistry at the Technical University of Machala, Ecuador where he has served as Director of Chemical Research Center and Director of the Center for Technology Development. Your research lines are Biotechnology and Applied Electrochemistry.   He has published  some scientific articles papers in reputed journals such as New Biotechnology, Progress in Organic Coutings, Talanta, Advances in Chemistry and Analytical Chemestry Research.

Abstract:

The objective of this research was to develop and validate a voltammetric method for the determination of antimony in aqueous medium. First, solutions of 5, 10, 15 and 20 mg L-1 of Sb were prepared, using 0.5M phosphoric acid as supporting electrolyte. Additionally, nitrogen was bubbled at 99% purity to remove oxygen from solutions. To measure the concentration of antimony the anodic stripping voltammetry technique was applied, by using a potentiostat multi-channel PARSTAT mark with Versa Princeton Applied Research Studio software. To carry out the registration of voltammograms, a three-electrode system was used, which consisted of glassy carbon as working electrode, Ag / AgCl as reference electrode and a platinum electrode as a counter electrode. In a first stage of the process, a chronoamperometry to E = -1.2 V was applied for a time pre-concentration of 50 s, to achieve this electrodeposition of metallic antimony (Sb0) on the surface of the glassy carbon electrode. Next, a linear sweep voltammetry with potentials between    -1.2 V and Ei = Ef = 0.5 V was applied at a rate of ν = 20 mV s-1. To validate the method for quantification of antimony determined linearity, precision, accuracy, detection limit and quantitation limit. The linearity of the method was demonstrated from the proportionality coefficient of 0.9961. The coefficient of variation (CV) had a value of 14.2%, indicating that the accuracy of the method is acceptable. Meanwhile the accuracy is within the criteria for consideration of the method, because a 114% recovery was determined. Additionally it was found that the detection limit and quantitation limit values ​​correspond to 1.45 mg 4.42 mg L- 1 and L 1 respectively.

Biography:

Marie Colmont has completed her PhD at the age of 25 years from Lille University and postdoctoral studies from Stockholm University. She is actually associate professor at ENSCL (Ecole Nationale Supérieure de Chimie du Lille) and researcher at UCCS (Unité de Catalyse et de Chimie du Solide) . She has published 45 papers in reputed journals.

Abstract:

The search for new non-centrosymmetric materials is still attractive do to their various related properties such as piezoelectricity, ferroelectricity or pyroelectricity... Particularly, Se4+ cations are fascinating because of its stereo active lone pair usually related to asymmetric environments. The crystallochemistry of selenium is particularly favorable because, in case of association with a transition metal and another  lone paire cation such as Pb2+ or Bi3+, the chances to obtain asymetric units and as a consequence non-centrosymmetric crystal structures are enhanced. From an experimental point of view, two synthesis routes are prefered: (1) CVT: chemical vapor transport and (2) hydrothermal synthesis. Particularly, they allow the simulation of natural conditions growth of minerals.

In this talk, after a brief sum up of advantages of each method, several chemical systems will be presented among those with nickel1, lead2, copper3 and bismuth4. Each time, experimental details will be presented along with isolated crystal structures.

As an example, the results obtained with copper are presented figure 1. Crystals of K[Cu5O2](SeO3)2Cl3 were isolated from the warmest zone of the sealed tube. This structure is related to those of a mineral called illinskite. They will be discussed during the presentation.

 

Biography:

Geeta Verma has completed her Ph.D at the age  of 26 years  from Central drug Research Institute Lucknow and Awadh University, Faizabad.. She has published 16 research papers including interdisciplinary topics in reputed International Journals. Awarded patent during CDRI research work 2003, Best Professor of the year 2015 from M.P. Employees Jankalyan Sangh. ,UGC Sponsored Research Project work done by her published and selected  as Best paper  award by International Academy of Science and Technology  2015 and Excellence in Service on Independence day 2016.  She has won the Indus Foundation awards for Teaching Excellence 2016.Her suggestions for family problems were selected as a winners in Daily Newspaper.

Abstract:

Green Chemistry is an approach to the synthesis, processing and use of chemicals that reduces risks to humans and the environment. A synthesis of benzopinacol  from benzophenone  is carried out using ethanol as a solvent.  This ia a free radical reaction and reduction of benzophenone occurred by sunlight via UV radiation.  Benzopinacol is a catalyst of the formation of unsaturated polyesters. It is also used as an  organic synthesis intermediate and as an initiator of polymerization by free radicals . Characterization of Benzopinacol was done by using spectroscopic technique like IR,NMR etc. Results positively show that  solvent ethyl alcohol  can be used as an alternative for photoreduction of benzphenone in case of non availability of  isopropyl alcohol.

Biography:

Harish Kumar has completed his PhD at the age of 29 years from MD University, Rohtak and postdoctoral studies from MD University, Rohtak. He is the Incharge of Chemistry Dept., a premier University. He has published more than 71 research  papers in reputed journals and has been serving as an editorial board member of repute. He has attended and presented his research work at 47 international and national confernces/seminars.     He was awarded International Research Staff Exchange Scheme (IRSES) and Summer Research Fellowship.

Abstract:

The rapid, unambiguous detection and identification of Biological Warfare Agents (BWAs) with early warning signals for detecting possible biological attack is a major challenge for military, health and other government defence agencies. The current research is focused on development of amperometric biosensors for the detection of biological warfare agent. For this purpose, a carbon based (Graphene) working electrode containing enzyme alkaline phosphatase, petroleum jelly, cellulose acetate and Poly Vinyl Pyrolidone (PVP), Ferrocene, Horseradish peroxidise, aq. KOH was fabricated. A three electrodes based electrochemical biosensor was used for the electrochemical detection of Baccilus cerrus as biological warfare agent in the presence and absence of Fe3O4 nanoparticles. Fe3O4 nanoparticles were synthesized by sol-gel technique and were characterized by UV-visible, FTIR, TEM and XRD techniques. Change in current response and OCP values help in the detection of biological warfare agent in presence and absence of Fe3O4 nanoparticles. Effects of temperature, stirring and Fe3O4 nanoparticles on the BWA have also been investigated. Storage, stability and reusability of electrochemical biosensor was tested. Optimum working conditions of electrochemical biosensor was also tested. Effect of temperature on current response of the biosensor was also investigated. Graphene based electrochemical biosensor helps in easy, quick and efficient detection of biological warfare agents.

Biography:

Hanan Elnagdy are an international research scholar in Dibrugarh university, India. She is originally from Egypt, she has a ten year experience in safety and occupational health in particular the safety precautions in chemail using and environmental applications.

Abstract:

1,2,3-triazole ring is not natural ring, but the benefits of triazole ring are increasing rapidly in last decays to involve in several applications; medical agents, pharmacological activities, in addition to polymer applications. Huisgen innovation the 1,3- dipolor cycloaddition reaction between azids and terminal alkynes have been considered as an important route to synthesis the disubstituted-1,2,3-triazole. The Huisgen work had supported the work for sharpless2 and his co-workers to reveal a new concept that called the click chemistry with the high regioselectively and high quantitative yield providing. Sharpless introduced the copper catalyst Cu (I) as the main catalyst for the click reaction for one-pot azide-alkyne cycloaddition reaction (CuAAC) to induce the formation for disubstituted-1,2,3-triazole with the high yield production in room temperature.

Because of the contamination of The homogenous copper catalyst by final product and hardly recovering for the catalyst, the conversion for heterogeneous catalysts have been better  solutions. The advantages of heterogeneous catalysts exhibit from easily separated from the reaction mixture and most of time reusing. The heterogenous catalyst system used Cu (I) with
various support for copper (zeolit,silica) to introduce for click reaction, or as corporation systems with catalyst; e.g ligands and ionic liquid supported Cu (I). Nowadays the  nanotechnology for catalyst is clear by Cu (0).

The short time and efficient synthesis are the objectives for all chemists. The new route of synthesis 1,2,3- traizole follows these objectives. One-pot cycloaddition reaction for azide and
terminal alkyne is established to produce the 1,4- disubstituited 1,2,3-triazole by using the heterogeneous clay supported copper(II) nitrate(claycop), with hydrazine hydartate as reducing
agent for Cu (II) to Cu (I). The efficiency of this route is high purities for the main products, the availability for applied by different azids and alkynes with high yields under mildconditions, in addition the simplicity for recyclable the catalyst.