Giulia Tarantino
Cardiff University, UK
Title: Decarboxylative fluorination of carboxylic acids with heterogeneous catalysts
Biography
Biography: Giulia Tarantino
Abstract
Fluorinated compounds find application in most fields of the chemical industry, such as agrochemicals, pharmaceuticals and materials . Furthermore, 18F compounds are widely used as tracers for positron emission tomography (PET) .Unfortunately, the synthesis of fluorinated molecules is difficult because of the C-F bond strength and,although several breakthroughs have been observed, fluorination reactions are still challenging, particularly, C(sp3)-F bond synthesis. Recently, several studies have been demonstrating that transition metals such as Fe(II), Ag(I) or Pd(II) can react with fluorinating reagents like F-TEDA giving new C(sp3)-F and C(sp2)-F bonds . However, many of these methods require stoichiometric metal loadings, and heterogeneous catalysts –typically preferred for several process intensification reasons – are rarely employed. In this context, supported Ag supported nanopaticles on titania have been prepared and, for the first time, effectively employed for decarboxylative fluorination of aliphatic carboxylic acids.