Josef Jampilek
University of Veterinary and Pharmaceutical Sciences Brno, Czech Republic
Title: Design of new antibacterial agents
Biography
Biography: Josef Jampilek
Abstract
Bacterial infections represent an increasing worldwide threat that is caused by general immunosuppression (primarily by tumour treatment, administration of immunosuppressive agents, wide-spectrum antibiotics and corticoids), a significant increase in the number of diabetic or HIV-positive patients and development of resistance to commonly used drugs. Moreover, the resistance to second- or third-choice drugs can also be found. Development of cross-resistant or multidrug-resistant strains is a great problem as well. Selection of resistant microorganisms is especially caused by irrational and unavailing application of antimicrobial agents in human and veterinary medicine as well as agriculture. Drug-resistant microorganisms initially occurred only in hospitals, but then they expanded to the community, and currently bacterial resistance is a global problem. Thus, it can be stated that significant resistance to antimicrobials can be found at both Gram-positive and Gram-negative bacteria that cause serious infections. Bacterial resistance may complicate the treatment of infections regardless of how mild these infections were at the early stage. Increasing bacterial resistance refers to the urgency to design new effective antibacterial drugs. At present design and discovery of antimicrobial agents can be divided into 3 basic approaches: i) design of new entities from new chemical classes influencing new targets; ii) design of new entities from new chemical classes influencing known targets; iii) development of me-too drugs. This contribution is focused on new potential antibacterial agents, which structure contains an amide or carbamate moiety as an essential fragment causing a significant antibacterial activity.