Bogumil Brycki
Adam Mickiewicz University, Poland
Title: Designed bispecific molecules selectively inhibiting both JAK2 and HDAC at low nanomolar concentrations
Biography
Biography: Bogumil Brycki
Abstract
The inhibitory action of surfactants in aqueous solutions is due to a physical adsorption or chemisorption of surfactant molecules onto the metal surface, depending on the charge on the solid surface and the free energy change of transferring a hydrocarbon chain from water to the solid surface. The adsorption of a surfactant markedly changes the corrosion resisting property of a metal thus the study of the correlation between the adsorption and degree of a corrosion inhibition are of a considerable importance. Gemini surfactants are multifunctional surfactants which have two amphiphilic groups connected by a spacer. Spacer can be hydrophobic or hydrophilic, flexible or rigid, can contain heteroatoms (oxygen, nitro gen, sulphur) or groups with π-electrons. These compounds have attracted considerable interest in recent decades because of their exceptional structural feature and versatile applicability. Gemini surfactants exhibit properties superior to those of conventional surfactants (cmc, γ, MIC, solubility). During recent years, an increasing interest has been focused on the investigation of the corrosion inhibition behavior of gemini surfactants in various aggressive media. In the present paper, the efficiency of three novel gemini cationic surfactants as potential corrosion inhibitors were investigated by electrochemical methods.