Jean-Bernard Regnouf-de-Vains
Universite de Lorraine, France
Title: From discrete to supported antibacterial calixarenes: Toward bacteriophilic materials
Biography
Biography: Jean-Bernard Regnouf-de-Vains
Abstract
We have conceived calixarene-based highly organized polycations thought to interact deleteriously with bacterial surface anions. The expected antibacterial behavior against various reference or resistant Gram negative or Gram positive bacteria, and on M. tuberculosis has been demonstrated in vitro. Various investigations involving AFM, Langmuir film studies and modelisation gave preliminary informations on their possible antibacterial mechanism, apparently related , as initialy thought, to a strong interaction with bacterial membrane. Taking that into account, we proposed to transpose these properties at the surface of solid support by a covalent grafting, hoping at least for a bacteria sequestering behavior of the new materials, in fine a possible antibacterial one. We will present the synthetic strategy developed for passing from discrete to supported antibacterial calixarene, and the bacteria sequestration results we have obtained by capillary electrophoresis in this approach.
