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Chuan-Fan Ding

Chuan-Fan Ding

Fudan University, China

Title: Specific inclusion complexation of cyclodextrin with amino acids revealed by ion mobility-mass spectrometry and molecular dynamics

Biography

Biography: Chuan-Fan Ding

Abstract

Host-guest complexes have been widely investigated by electrospray ionization mass spectrometry; however, it is questionable whether the inclusion can be preserved in gas-phase analysis without solvent molecules. Herein, complexes involving beta-cyclodextrin and amino acids of Gly, Leu and Phe are investigated by ion mobility-mass spectrometry. It is found that the complexes abundance is increasing as the hydrophobicity of amino acid side chain increases in competitive reactions, revealing Phe and Leu interact more strongly with β-CD than Gly molecule. Based on ion mobility spectrometric analysis, complex ions formed with different size amino acids exhibited very similar collision cross sections, so it is proposed that inclusion complexes can be preserved in gas phase. Additionally, complex structures in gas phase are calculated via force field to further identify our proposal.