4^th European Chemistry Congress

Biography

Biography: David L Officer

Abstract

The ability to selectively transport chemical species in a controlled fashion, typically against chemical and electrochemical gradients, has been the cornerstone of the development of complex natural systems. In 2013, the Nobel Prize in Physiology or Medicine was awarded to Rothman, Schekman and Südhof "for their discoveries of machinery regulating vesicle traffic, a major transport system in our cells".  Vesicles are closed cellular structures formed from lipid bilayers that are used to actively transport macromolecules from inside cells to the outside fluid by a process known as exocytosis or between cells by a variety of mechanisms. In exocytosis, the macromolecules are contained in the vesicle that isolates them from the rest of the cell and which eventually fuses with the cell membrane to release the macromolecular cargo to the outside of the cell.  Emulating such structures and processes in the fluid environment is considered one of the grand challenges confronting nanoscience today and has the potential to add revolutionary capabilities to fluidic platforms that could be used to transport medicine in the human body, act as chemical messengers for signal transduction in sensing or other systems, move cargo around microfluidic devices, or even be utilized for transport in artificial cellular systems.

We have developed lipophilic droplets whose movement and direction can be controlled on or in an aqueous medium solely by photo-driven “chemopropulsion” (photochemopropulsion). In this presentation, we will demonstrate how the droplets can be “pushed” or “pulled” by light in 3D, are able to carry “cargo”, and undertake sequential chemical reactions through the interaction of two or more droplets.