Tuanli Yao
Shaanxi University of Science and Technology, China
Title: Palladium catalyzed domino heck/aryne carbopalladation/c-h functionalization: Synthesis of heterocyclefused 9,10-dihydrophenanthrenes
Biography
Biography: Tuanli Yao
Abstract
Arynes generated from the corresponding o-(trimethylsilyl)aryl triflates have emerged as powerful synthons in organic synthesis. Aryne annulation reactions with intramolecular C-H functionalization can be a powerful method for the synthesis of polycyclic compounds. We developed a novel palladium-catalyzed domino Heck/aryne carbopalladation/C-H functionalization reaction using in situ generated arynes, in which three new C-C bonds and a carbon quaternary center are formed. This methodology affords moderate to excellent yields of heterocycle-fused 9,10-dihydrophenanthrenes