Diego Gamba-Sanchez
University of Los Andes, Colombia
Title: Synthesis of 5-membered heterocyclic systems by the pummerer reaction
Biography
Biography: Diego Gamba-Sanchez
Abstract
The Pummerer reaction has been studied for many years as a powerful methot to form C-Nu bonds, its aplications in total synthesis of natural products has been recently reviewed showing its grate potential. We recently publised a new method to obtain oxaxolines by Pummerer chemistry, and the goal of the current study is to extend the scope of this methodology to the synthesis of other heterocylcic systems. The results include approaches to pyrroles, ozaxoles, thiazoles and the application of the methodology to the total synthesis of siphonazole and muscoride A.