Day 2 :
Institute of Organic Chemistry Polish Academy of Sciences, Poland
Slawomir Jarosz has completed his PhD in 1979 at the IOC, PAS and he is now a full professor at this Institute since 1999. Since 2011 he is a general director of this institute and, since 1999, a head of the carbohydrate group. He spent 1 year (1980) as a post-doc in the group of professor Bert Fraser-Reid (Maryland, US) and 1 year as a visiting scientist (1988) at Duke University (US). He published ca 190 papers and promoted 18 PhD students.
The concise approach to bicyclic imino- and carbasugars from simple monosaccharides will be presented. First method is based on the fragmentation of sugar allyltins (e.g. 5) into dienoaldehyde 1 which is further converted into carbasugars (3, 4b) or iminosugars (2, 4a. The configuration at the ring junction (cis-decalin and trans-hydrindane), is fixed which results from the mechanism of the cyclization of intermediates.Problem of obtaining the alternative trans isomers of decalin was solved by an introduction of both substituents in the trans-relation before cyclization (route b). Aldehyde 1 was also used for the preparation of iminosugars (e.g. 2 and 4a). Besides the ‘allyltin’ approach to iminosugars, we have elaborated also another one starting from sugar derived bromonitriles (e.g. 9) which allow for the efficient preparation of bicyclic iminosugars.
Institute of Protein Research RAS, Russia
Keynote: What is responsible for atypical dependence of the rate of amyloid formation on protein concentration: Fibril-catalyzed initiation of new fibrils or competition with oligomers?
Time : 10:30-11:00
Alexei Finkelstein done his PhD in biophysics, Moscow PhysTech., 1976, DSc biophysics, Moscow University 1991. Author of >250 scientific papers and books "Protein Physics", (five Russian, two english and two chinese editions), and "physics of protein molecules" (in Russian). citation index by google scholar about 8400, hirsch index about 42. Since 1970, member and since 1999, head of protein physics laboratory at the institute of protein research, RAS. Since 1998, full professor of the Moscow University. Awards from FIRCA, INTAS, CASP, HHMI (3 times), RFBR, RSF, moscow grant, etc. State Prize of Russia in Science (1999), elected to the Russian Academy of Sciences (2008).
An abnormal dependence of the rate of amyloid formation on protein concentration has been recently observed by Meisl et al. for Aβ40 peptides associated with alzheimer’s disease. To explain this effect, Meisl et al. proposed a novel mechanism of fibril growth, the fibril-catalyzed initiation of fibril formation. Here we offer an alternative explanation of the observed anomalous kinetics: formation of metastable oligomers competing with fibril formation by decreasing the concentration of the fibril-forming free monomers. We show that the oligomer sizes resulting from the anomalous dependence of the fibril growth rate on protein concentration are close to the sizes of oligomers observed by electron microscopy. This work has been supported by the RSF grant 14-24-00157.
- Biological Chemistry | Nuclear Chemistry | Petro Chemicals | Multi-disciplinary Chemistry | Chemistry Education | Inorganic Chemistry
Alexei V Finkelstein
nstitute of Protein Research RAS, Russia
JSC Fine Chemicals R & D Centre, Russian Federatio