Hailin Wang
Chinese Academy of Sciences, China
Biography
Hailin Wang has his expertise in epigenetics, in particular, DNA methylation and demethylation. He developed ultrasensitive analytical technologies (UHPLC-MS/ MS, qPCR, genome-wide sequencing) for characterization and functional study of DNA 5-methylcytosine and its oxidation intermediates. He for the first time showed the enhancement of genome-wide 5-hydroxymethylcytosine by nutrient vitamin C, revealing a role of vitamin C in the regulation of DNA modification, and his study established a direct lin among vitamin C, Tet dioxygenases, and DNA methylation. He further extended these technologies for study of other DNA modifications, and as a world-wide seminal work, he discovered new DNA modification (N6-methyladenine) in high eukaryotes (Cell, 2015). He also has his expertise in ultrasensitive analytical technologies (e.g., capillary electrophoresis-laser induced fluorescence polarization, single molecule fluorescence imaging, and UHPLC-MS/MS) for detection of carcinogenic DNA adducts and for study of DNA-repair proteins interactions. He published 100 peer-reviewed papers on leading journals, including Cell, Cell Stem Cell, Mol Cell, Proc. Natl. Acad. Sci. USA, J. Am. Chem. Soc., Nucleic Acids Research, Analytical Chemistry.
Abstract
Abstract : DNA N6-methyladenine modification from unicellular eukaryotes to mammals