Lars Baltzer
Uppsala University, Sweden
Biography
Lars Baltzer is a professor in organic chemistry at uppsala university since 2004. He has a well-documented and longstanding interest in research topics related to catalysis and molecular recognition based on fundamental principles of physical-organic chemistry. He has introduced catalytic sites, demonstrated rate enhancements of several orders of magnitude and proven the formation of enzyme-substrate complexes in proteins he has designed from scratch. More recently he has become engaged in research on the molecular recognition of proteins by polypeptide conjugates, for the purpose of increasing affinities and selectivities for proteins of biomedical interest. Affinity enhancements due to peptide conjugation of four orders of magnitude, increased selectivities as well as improved pharmacokinetic and pharmacodynamic properties have been demonstrated. He has expertise in molecular design and the quantitative evaluation of structure and activity relationships especially those related to protein recognition. Aleksandra Balliu obtained her Ph D in the laboratory of Lars Baltzer, working on aspects of the polypeptide conjugate technology.