European Chemistry Congress June 16-18, 2016 Holiday Inn Rome Aurelia Rome, Italy

Adriana A Lopes is from Universidade de Ribeirão Preto, Brazil.

Natural products and their analogues have been sources of numerous important therapeutic agents. The medicinal plant U. guianensis (Rubiaceae) cultured in vitro produce four oxindole alkaloids that displays anti-tumoral activity. Natural products can be modified by several approaches, one of which is precursor-directed biosynthesis (PDB). Thus, the aim of this work was apply precursor-directed biosynthesis approach to obtain oxindole alkaloids analogues using in vitro Uncaria guianensis. Plantletes were cultivated into culture medium supplemented with 1mM of 6-fluoro-tryptamine, the indol precursor of alkaloids biosynthesis. U. guianensis explants were maintained at 25±2°C, 55-60% relative humidity under the same photoperiod and light intensity. After 30 days, a methanolic extract from U. guianensis was obtained and analysed by HPLC-DAD analytical procedure. The chromatogram showed four natural alkaloids (mitraphylline, isomitraphylline, rhynchophylline and isorhynchophylline and four additional peaks. Semi-preparative HPLC allowed isolation and purification of these four oxindole alkaloids analogues and the identity of the peaks was confirmed from high-resolution MS data (HRESIMS/MS in positive mode). All data confirmed that Uncaria guianensis produced fluoro-oxindole alkaloids analogues.

Melitta Patrícia Kiss got her MSc degree in Chemistry at University of Pannonia, Veszprém, Hungary. Now, she is a PhD student at the Department of General and Inorganic Chemistry at the same university. In her research work, she studies the formation of lanthanide porphyrin complexes from equilibrial and kinetic aspects since 6 years.

Larger-sized metal ions are not able to coplanarly fit into the cavity of the porphyrin ring; they are located out of the ligand plane, resulting in out-of-plane (OOP or sitting-atop=SAT) complexes OOP position promotes the formation of bis- or oligoporphyrins, so-called sandwich complexes. Lanthanide(III) ions offer good opportunities to fine tune the out-of-plane distances, utilizing the well-known lanthanide contraction. The UV-Vis absorption bands of SAT complexes represent redshift compared to the free-base ligand. SAT complexes can be used as photocatalysts in redox reactions, as photosensors in the medical science in luminescence imaging and as polymer diodes in cancer treatment. We investigated the reaction between the 5,10,15,20-tetrakis(4-sulfonatophenyl)porphyrin and early lanthanide(III) ions (La-Gd), as well as the effect of the ionic strenght, the temperature and the potential axial ligands on these processes. The structures of different complexes were identified on the basis of their UV-Vis absorption spectra. The bidentate O-donor acetate and glycol, as well as the monodentate ethanol and chloride can enhance the coordination of the first porphyrin ligand, due to their axial effect, but they can hinder the connection of an additional porphyrin. In the presence of non-coordinating perchlorate anion, bisporphyrins can form, too. At lower temperatures, the lanthanide(III) ions were not able to coordinate into the cavity of the macrocycle, to the softer pyrrolic nitrogens, rather to the sulfonato groups, to the harder oxygens; resulting in the formation of the free-base ligands’ tail-to-tail dimer. So the coordination position of metal ion can be influenced by temperature.

Orsolya Fónagy has started her PhD in 2014 at University of Pannonia. Her PhD topic is “Investigation and development of water treatment procedures based on heterogeneous photocatalysis”. She is a co-author in two publications at scientific journals.

Heterogeneous photocatalysis is a worldwide researched Advanced Oxidation Process. It can be successfully applied for degradation of various organic pollutants into harmless or less harmful compounds. The efficiency of this technology can be increased in multiple ways, thus it has the flexibility for being used in practical application. The efficiency can be significantly enhanced by the combination with other oxidative procedures such as ozonation and by using new kind of catalysts or modifing their surface with precious metals. The latter helps the charge separation therefore slows down the recombination of holes and electrons. Furthermore with the “coloring” of the semiconductor there is a possibilty to extend the light absorption range of the catalyst to the visible light wave lengths. Our research group studied TiO2 and kaolinite based heterogenous photocatalysis by the degradation of different model compounds. In this work, we summarize our results regarding the mineralization of benzenesulfonic acid and oxalic acid on the previous two catalysts.

Péter Hegedűs has completed his M.Sc. in Environmental Engineering at the age of 25 years from University of Pannonia. He is a first year PhD student at University of Pannonia Department of General and Inorganic Chemistry. His subject is: The preparation and characterisation of immobilised photocatalyst, and application for the degradation of pollutants.

The newer chemicals that appears nowdays can’t always be treated with the current sewage treatment methods. Keeping the environmental aspects in mind, new procedures should be developed. Triton X-100 is one of the most widely applied man-made nonionic surfactants. This detergent is utilized as both household and industrial cleaning agent. Triton X-100 can hardly be degraded by biological treatment under anaerobic conditions, and even in aerobic systems it can be just partly mineralized. Thus, it can reach natural waters, damaging various living organisms there. Hence, application of a more efficient degradation method is indispensable for the total mineralization of this surfactant. A possible solution of this problem is the application of heterogeneous photocatalysis. It is an advanced oxidation process that uses UV irradiaton to form highly reactive radicals on the surface of a semiconductor catalyst. We have thoroughly examined the photocatalytic degradation of Triton X-100 under various circumstances. The process was monitored by following the spectral changes, the organic carbon content, and the actual concentration (UHPLC method). It has been established that Triton X-100 could be mineralized by TiO2 mediated heterogeneous photocatalysis However, one obstacle to the in field use is that if the catalyst is used in slurry form, the catalyst separation from the liquid phase is difficult and makes the technology more expensive. This problem can be eliminated if the catalyst is immobilized. We managed to create a foil catalyst from poli(vinyl-alcohol) and Degussa P25 TiO2 which is capable of breaking down the modell compound.

Marius Zaharia is a 2015 graduate of Alexandru Ioan Cuza University of Iasi, Department of Chemistry, and pursuing his doctoral study in Doctoral School "Chemistry and Life and Earth Sciences". Consequently, he is the Director of project Grants for young researchers of UAIC (Contract 21754/03.12.2015), project from Alexandru Ioan Cuza University of Iasi. He has published 8 papers and 4 papers accepted to be published in reputed journals and presented several research papers at various national and international conferences.

Although the dinitrophenols and related compounds are deeply poisonous, they are still used as pesticides, drugs or even weight loss agents. Today, DNP is used by bodybuilders, often illegally, to rapidly lose body fat before contests. Numerous pesticides act as uncoupling agents of oxidative phosphorylation at low concentrations, and inhibit the electron transport chains, probably before cytochrome C at higher concentrations. Dinitrophenol disrupts the H+ gradient reducing ATP synthesis. The permeability of mitochondrial membranes to protons is increased by the conversion failure from ADP to ATP. Under these conditions, much of our food that we eat could not use for ATP synthesis leads to weight loss. The difference between weight loss and death is only a small concentration change in dinitrophenol, making the drug dangerous. The level of toxicity of dinitrophenyl derivatives is closely related to inhibition of ATP production even in the presence of oxygen, which leads to alcohol formation in yeast and plant cells. Since the level of toxicity of dinitrophenyl derivatives depends on their property of uncoupling the respiration from ATP synthesis, we have recently patented a method to identify the uncoupling agents as well as to quantify the intensity of such activity by determining the ethanol produced in living cells of some biological materials. The simplest way to do that is to measure the ethanol liberated in presence of the uncoupling agents. We have colorimetrically determined alcohol by the reduction of the orange-colored potassium dichromate (K2Cr2O7) to green colored salts of chromium (III), in the presence of sulfuric acid (H2SO4). A well-defined volume of sample is taken from the green colored solution, diluted with distilled water, and its absorbance measured in a spectrophotometer or colorimeter. The calibration curve is carried out with different concentrations of ethanol.

Dr. Adam Huczynski was born in Poznan, Poland. In 1979, graduated from the Adam Mickiewicz University in Poznan with M.Sc. (2004, Physics), M.Sc. (2004, Chemistry) D.Sc. (2008, Chemistry) and D.Sc. habilitation (2013, Chemistry) degrees. Actually he is an associate professor at the Faculty of Chemistry, Adam Mickiewicz University. His major research interests are organic and bioorganic chemistry, spectroscopy and medicinal chemistry, mainly ionophore antibiotics and other natural compounds.

Colchicine is a plant alkaloid that shows antimitotic effects on a number of cancer cell lines. It binds to tubulin, inhibiting the formation of microtubuli and, thus, blocks mitosis. Herein, we report that colchicine can be functionalized at C-ring by a simple reaction with benzyl amines to yield various active derivatives. These compounds were characterised spectroscopically and their antiproliferative activity against four human tumour cell lines (HL-60, HL-60/vinc, LoVo, LoVo/DX) was evaluated. Additionally, the activity of the studied compounds was theoretically predicted using computational methods involving molecular docking of the colchicine derivatives to β-tubulin. The experimental and computational results are in very good agreement indicating that the antimitotic activity of colchicine derivatives can be readily predicted using computational modeling methods.

Violina T Angelova has completed his PhD in 2004 from Bulgarian Academy of Sciences, Institute of Organic Chemistry with Centre of Phytochemistry, Sofia, Bulgaria. She is an Assistant Professor of Medical University of Sofia, Faculty of Pharmacy, Department of Chemistry. She has published more than 15 papers in reputed journals.

A series of 2H-chromene based hydrazones 5a-m, 6a-c and 7a-c were synthesized by condensation of 2H-chromene-3-carbaldehydes with varied substituted hydrazides. The structure of the newly synthesized compounds were confirmed by 1H NMR, 13C NMR, FTIR and HRMS (ESI) spectroscopy and the E-configuration of the compounds 7a and 7c was proven by X-ray crystal structure analysis. In vitro antimycobacterial activity of the newly synthesized hydrazones was tested against Mycobacterium tuberculosis H37Rv and compared to that of first-line antituberculous drugs isoniazid (INH) and ethambutol (EMB). The most active compounds 5j, 5h, 5l, 7b, 7c demonstrated a nanomolar inhibitory potency with MICs 0.13-0.74 μM, but noteworthy they proved to exert minimal associated cytotoxicity in the human embryonal kidney cell line 293 T. Hydrazone 5j was the most potent antituberculous agent with a minimal inhibitory concentration (MIC) of 0.13 µM. The activity of the tested compounds varied depending on the substituents and the log P values. Quantitative structure-activity relationship (QSAR) model was derived to guide the further lead optimization. Low log P values and 5 rings in the molecules proved to be optimal for nanomolar activity. These results could be considered a good starting point for further studies to develop new lead compounds.

Chang Wook Song received his BS in 2013 from the Department of Chemistry, Busan National University and MS in 2015 from POSTECH. He is currently pursuing his PhD at the Department of Chemistry, POSTECH, under the supervision of Professor Kyo Han Ahn.

Fatty acids play important roles in biological processes, functioning as a cell membrane component, growth and survival pathways, signalling for metabolic regulation, and inflammatory and metabolic responses. Unsaturated fatty acids exert various biological processes depending on their overall shape due to cis and trans isomerism. Therefore, selective detection of fatty acids by their shape is of interest but is a challenging goal. Herein, we report the liposome sensing system as a simple yet efficient assay tool for discrimination of cis-fatty acids from trans- and saturated fatty acids. The liposome showed a turn-on type fluorescence change and distinct color change. The molecular interactions between the liposome and cis-fatty acids showed 1:2 and 1:1 (liposome component/fatty acids) binding stoichiometries in the cases of mono- and di-oleyl fatty acids, respectively. The colorimetric response indicated that it has good linearity up to the equivalent point. Furthermore, we applied liposome for monitoring residual cis-fatty acids in soybean oil product after heating at 200ºC.

Juryang Bae received her BS from Pusan National University in 2013. Currently, she is a PhD candidate at Pohang University of Science and Technology (POSTECH).

The advantage of fluorescent imaging for biomaterials is operationally simple, cost-effective, noninvasive, high sensitive detection and visualization of organisms at a subcellular level. In tissue imaging, however, autofluorescence from biological molecules under excitation at UV−Vis wavelengths lowers signal to noise ratio. Most of biomolecules absorb and emit light of green region. So, a novel class of fluorophores excited in the near-infrared region is necessary to suppress this critical issue. Two-photon absorbing dyes are one of the methods to satisfy this criterion. They have several advantages not only reduced autofluorescence, but also increased penetration depth, and high special-resolution. In addition, they diminish photodamage and photobleaching as well. Acedan, 6-acetyl-2-(dimethylamino) naphthalene, and its derivatives are widely used for two-photon dyes. But their maximum absorption wavelengths (~370 nm) are rather short for two-photon excitation (~740 nm) which shows strong autofluorescence and limits the depth in tissue in microscopic imaging of tissues. Herein, we have developed compact π-extended acedan derivatives. They have the longer maximum absorption wavelengths more than 400 nm and sufficient two-photon absorption properties. One of the new dyes that can be excitable at 1000 nm under two photon excitation condition is photochemically stable and biocompatible. Also it has environment-sensitivity and readily penetrate the blood-brain barrier, allowing in vivo fluorescence imaging of Aβ plaques in a live mouse model of Alzheimer’s disease.

Hyeonjin Park is from Pohang University of Science and Technology, South Korea.

Detecting lysosomal Zn(II) is an important issue because it acts as downstream marker for the LMP process. Development of fluorescent probe which can detect lysosomal Zn(II) ions is necessary to study the oxidative stress levels in biological systems. Herein, we have developed innovative two-photon probe using naphthalimide dye composed of N,N-di-(2-picolyl)ethylenediamine (DPEN) ligand and a morpholine unit. The probe can detect Zn(II) ions in lysosomes with high sensitivity and selectivity over the most competing Cd(II) ions. The probe can also enabled fluorescence imaging of mouse brain tissues under two-photon excitation at 900 nm. The probe can be an effective tool for studying biological processes related to lysosomal Zn(II) ions by two-photon microscopy.

Hyerim Kim is from Pohang University of Science and Technology, Republic of Korea.

The donor-acceptor (D–A) type dipolar dyes have been widely used as fluorophores in molecular probes and biological tags.1 In general, this type fluorophores emit strongly in organic solvents but poorly in aqueous media. To enhance the poor emission behaviour of dipolar dyes in aqueous media, we carried out a systematic structure variation of the donor, amino substituent of acedan which is an important two-photon dye.2 We have identified several factors that influence the emission behaviour of the diopolar dyes in aqueous media by inhibiting the liable factors for poor emission: 1,3-allylic strain, rotational freedom, and hydrogen bonding with water. This rational approach can be applied to other dipolar fluorophores, as demonstrated for naphthalimide, coumarin, and (4-nitro-2,1,3-benzoxadiazol-7-yl)amine (NBD) dyes. The new acedan and naphthalimide dyes thus allow us to obtain much brighter two-photon fluorescent images in cells and tissues than in their conventional forms. As an application of these findings, a thiol probe was synthesized based on naphthalimide dye, which showed greatly enhanced fluorescence from the widely used N,N-dimethylamino forms. The results indicated that our approach has great potential for the development of efficient dipolar dyes and fluorescence probes for studying biological systems, particularly by two-photon microscopy.

K. Nakagawa has completed his PhD at the age of 27 years from The University of Tokyo. He studies as a postdoctoral researcher at The University of Tokyo, School of Science.

Various interesting functionalities have been reported on Prussian blue analogues, such as humidity sensitive magnetism. Prussian blue analogues have two types of cubic crystal structures. One of them is MAII[MBIII(CN)6]2/3•zH2O type (MA, MB: transition metal ions). There are vacancies of [MB(CN)6] in MA[MB(CN)6]2/3•zH2O, and water molecules are coordinated to MA ions and/or exist in the vacancy sites. Herein we report high ionic conductivities (σ) of 1.2×10−3 S cm−1 for Co[Cr(CN)6]2/3•zH2O (1) and 1.6×10−3 S cm−1 for V[Cr(CN)6]2/3•zH2O (2) at 293 K, 100%RH, respectively. As the humidity decreased, σ of 1 drastically decreased to 3.2×10−8 S cm−1 at 8%RH. This result indicates that the origin of ionic conduction is explained by Grotthuss mechanism, i.e., proton transfer is mediated by hydrogen-bonding network of water molecules. σ at 100%RH of 1 and 2 increased as temperature was increased. The plot of ln(σT) vs T−1 of 1 was linear and gave an activation energy (Ea) of 0.22 eV, whereas, the slope of the plot of 2 changed at an intermediate temperature. The Ea values in the high- and low-temperature regions were 0.10 and 0.19 eV, respectively. The folding point of 313 K corresponds to the magnetic transition temperature of 2, which indicates that an interference effect between magnetic ordering and proton conduction was observed.

Rong-Xin Yuan has completed his PhD in 2002 at Nanjing University. From 2002 to 2004, he worked at University of Bielefeld and University of Nottingham as a Postdoctoral fellow. Now, he is the Director of Jiangsu Provincial Key Laboratory of Advanced Functional Materials. He has published more than 50 papers in reputed journals and has been serving as an Editorial Board Member of the Journal of Soochow University (Natural Science Edition ).

Metal-organic frameworks (MOFs) have potential applications in the fields of sorption and separation, catalysis and luminescence. Here, a 3D compound {[Zn2(BPF)(NH2-BDC)2]}n (1) was constructed with 2,7′-bis(4-pyridyl)fluorine (BPF) and 2-aminoterephthalic acid (NH2-BDC ) as bridging ligand. The single crystal X-ray study showed that compound 1 displays pillar-layered structure. The solid-state emission spectra of the compound have been studied at room temperature. Compound 1 shows strong emission at 495 nm, which is stronger than that observed in the free BPF (424 nm). The enhancement of luminescence may be attributed to the chelation of ligand with metal center, which effectively increases the rigidity of the ligand and reduces the loss of energy by radiation decay. The band gap (2.75 eV) was measured by a solid state visible light diffuse reflection measurement method at room temperature. We select methylene blue (MB) as a model of dye contaminant to evaluate the photocatalytic effectiveness. Approximately 50% of MB was degraded in four hours under neon light at 500 W.

Bilgehan Güzel has completed his PhD at Çukurova University and Postdoctoral studies from Texas A&M University. He has published more than 9 papers in reputed journals and his research areas are organometallic complexes, catalysts, nanomaterials and scCO2 media.

Palladium-catalyzed carbon−carbon bond-forming reactions developed by Heck, Negishi and Suzuki, among others have made a critical impact on synthetic organic chemistry. In this regard, coupling reactions present wide applications in the production of polymers, agrochemicals, pharmaceutical intermediates, and high-tech materials. Palladium nanoparticles (Pd NPs) provide high activity in catalyzing Suzuki cross coupling reactions, due to their high surface to area ratio. Silica, activated carbon, carbon nanotubes and alumina are used as support materials for Pd NPs to provide heterogeneous catalysis for the reaction. Four different support materials have been used and their catalytic activities were investigated. Pd NPs were prepared by supercritical carbon dioxide deposition method and vic-dioxime derivative Palladium complexes were used as precursors. Supported Pd nanoparticles were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM) and scanning electron microscopy (SEM). XRD patterns showed that the size of nanoparticles changes between 2 and 10 nm.

Burcu Darendeli has completed her BSc from Hacettepe University and completed her MSc from Çukurova University. She still continues her PhD at the same university. Her research areas are organometallic complexes, catalysts, nanomaterials and scCO2 media.

Asymmetric reactions carried out using homogeneous catalysts are used in the preparation of many chiral compounds especially in pharmaceutical industry. Enantiopure chiral complexes play a major role in performing asymmetric synthesis in homogeneous catalysis reactions. There is a lot of interesting about chiral binaphthyl Schiff base complexes for using asymmetric reactions. Due to difficulties in separation of catalyst from products in purification steps and high cost of catalyst, researchers are seeking more convenient methods for synthesis. Hence researches continue to focus on supercritical fluids, ionic liquids and biphasic liquid systems as new reaction media. Especially homogeneous catalysts in supercritical carbon dioxide (scCO2) are often preferred in very common organic synthesis. In this work, Schiff base ligands were prepared from condensation of perfluorinated aldehydes with binaphthyl amines (Fig.1.). For this step, firstly perfluorinated aldehydes were synthesized, then the condensation was occurred. Transition metal complexes of this ligand were prepared as chiral catalyst for various asymmetric reactions in scCO2. Effect of reaction parameters such as pressure, temperature, reaction time, catalyst/substrate ratio on the enantio selectivity of catalyst were also be investigated.

Asli Ustalar has completed his MS from Kocaeli University. She is a PhD student in Kocaeli University.

Coumarin derivatives such as Scopoletin, Esculatin, Fercoprolone, Hohneliacoumarin, Angelicin, Psoralen and Aureptene have been found in nature and they possess many biological activities varying from anticancer, antioxidant, antibacterial, antifungal and anticougulant. It is well known that Mn(OAc)3 have been used as radical oxidant in the synthesis of dihydrofuran derivatives forming C-C bond between active methylene compounds and alkenes. In here, we performed the reaction of of 4-hydroxycoumarin and 4-hydroxypyrane with conjugated amide and esters promoted by Mn(OAc)3 leading to dihydrofurocoumarins and dihydrofuropyranes in moderate to good yields. All new compounds were characterisized by spectroscopic techniques. Also, we investigated enzyme (cGMP PDE- cyclic guanozine mono phosphate phosphodiesterase) inhibitions of these compounds.

In Jung Chang obtained his Bachelor’s degree from the department of chemistry at Chung-Ang University in 2015. She is currently a master student in the department of chemistry at the same University. Her research field is design of chemical probes for metal ions and anions. Her research interest is development of chromogenic and fluorogenic chemosignaling probes.

A new reaction-based probe for the fluorescence signaling of Hg2+ ions using dithiane derivative of ESIPT probe has been investigated. Probe showed prominent off-on type fluorescence signaling behaviour towards Hg2+ ions in aqueous DMSO solution. The interfering response of Cu2+ ions was efficiently removed by using a citrate buffer as a masking agent. By using citrate buffer, the selective signaling behaviour is not affected by the presence of other metal ions that are usually present in environmental samples. Hg2+ ions signaling by a large fluorescence enhancement (66-fold) was possible with a detection limit of 1.8 ï‚´ 10-7 M.As a test of a practical use for the designed probe, we created a test strip that could be used to detect Hg2+ ions in aqueous solution.

Min Jeoung Cho is currently a master student in the department of chemistry at Chung-Ang University. Her research field is design of chemical probes for metal ions, anions and oxidative species.

Detection and control of biological and/or organic pollutants in drinking and industrial waters are of the utmost importance, especially if the final usage is for daily human consumption or the production of foodstuffs. Hypochlorite, ionized form of hypochlorous acid (HOCl), is particularly important because it is widely used in household and industrial area as cleaning agent, disinfectants, and sanitizers. Because of its widespread usage and an excess level of OCl- is potentially harmful to the health of human and animals, development of simple and convenient signaling methods for its industrial and environmental applications is imperative. Based on a sulfonhydrazone of 2-acetyl-6-methoxynaphthone, a new hypochlorite signaling probe 1 was developed. The designed probe exhibited prominent off-on type fluorescence signaling behavior toward hypochlorite in aqueous solution by hypochlorite-triggered oxidative hydrolysis of sulfonhydrazone. Hypochlorite signaling by a large fluorescence enhancement (76-fold) was possible with a detection limit of 3.8 ï‚´ 10-8 M. The signaling of hypochlorite was not affected by the presence of other practical oxidants as well as common metal ions and representative anions. As a practical application, signaling of 1 for determination of hypochlorite levels in practical sample of tap water was conducted by using an easy-to-use smartphone as a detection tool.

Yun-uk Jung obtained his Bachelor’s degree from the department of chemistry at Chung-Ang University in 2015. He is currently master candidate in same university. His research interest is development of chromogenic and fluorogenic probes for biologically important species.

A simple optical sensor for the measurement of the water content of biofuel-relevant ethanol and 1-butanol based on the pyranine fluorophore was investigated. The diethylsulfonamide derivative showed pronounced absorption and fluorescent signaling in response to changes in the water content of ethanol and 1-butanol. The signaling is based on the increased dissociation of the hydroxyl group of pyranine in response to the increasing water content of the alcohol solutions. The signaling behavior of the sensors was analyzed readily by ratiometric measurements using the absorption and fluorescence characteristics of the undissociated and dissociated form. Upon derivatization to diethylsulfonamide, the signaling became more sensitive than that for its parent pyranine. The detection limit of the pyranine and diethylsulfonamide derivative for the measurement of the water content in ethanol was 1.0% and 0.03%, respectively. On the other hand, the detection limit of the diethylsulfonamide derivative for the determination of water content in 1-butanol was 0.02%, while underivatized pyranine was not useful due to the limited solubility of the sensor. The practical application of the measurement of the water content in ethanol and 1-butanol by a smartphone as an easy-to-use colorimetric device was also explored.

Sang Hun Lee studied chemistry which is his major for 6 years at Chung-Ang University, and completed bachelor’s degree on chemistry in 2015. He is presently on a master’s candidate. His main research area is organic synthesis of sensors signaling chemical species such as metal ion or oxidants which can be harmful for human and environment, or important in modern industry.

New boron triflouride-introduced 2(2',4'-dihydroxyphenyl) benzothiazole (2,4-DHBT) and benzimidazole (2,4-DHBI) was synthesized and its photophysical characteristic were investigated. Each compound was generated well by using 2-aminophenol or ortho-phenylenediamine with 2,4-dihydroxybenzaldehyde. 2,4-DHBT and 2,4-DHBI have difference flourescence patterns on the basis of the excited-state intra-molecular proton transfer (ESIPT) system. It is well known that ESIPT is significantly affected by the properties of solvent. UV-Vis data and emission spectra of each compound were observed in various type of solvent such as dichloromethane, acetonitrile, dimethyl sulfoxide and they showed stokes shift of 60-70 nm approximately. Furthermore, difference of spectra was noticed by comparing new compound to those without boron trifluoride. Absorption and fluorescence intensity depending on pH, in water with small amount of ethanol were also tracked and pKa value of individual derivatives were calculated.

Thoria Diab did her PhD from Paul Sabatier University, Toulouse, France. She has 3 papers in reputed journals, Journal of Hepatology is one amongst them. She ahs presented a abstract in a conference in France, and a chapter in an electronic book (Advnces in Genome Science, Chapter 6).

It was proposed for decades that natural products are more safe in therapeutics as compared to synthetic drugs. The aim of this study was to screen ethanol extracts of four Egyptian plants (Varthemia candicans, Peganum harmala, Suaeda vermiculata and Conzya dioscoridis) to study their antioxidant activity in vitro using DDPH (50% DDPH inhibition) and phosphomolybdate assays (as equivalent ascorbic acid/g dry weight), in addition to the total phenolic and flavonoid contents were estimated to find possible sources for future novel antioxidants in food and pharmaceutical formulations. Moreover, the anticancer activity of plants extracts against HepG2 cells using MTT assay was studied. The results revealed that Varthemia candicans extract was the highest one in both polyphenol and flavonoid contents. Furthermore, 50% DDPH inhibition showed that Suaeda vermiculata extract exhibit lowest IC50 against DDPH indicating it is the most effective. Taken together, the four investigated plants extract showed a potent antioxidant and antitumor activities that hold great promise to identify new natural therapeutic drugs. Further work is needed to study the mode of action of different extracts and more analyses to study their in vivo anticancer activities.

Abeer Abdel Hamid Ahmed Khamis is from the department of Biochemistry from Tanta University, Egypt.

Background: Calcineurin (CN) is a Ca2+/calmodulin- dependent phosphatase and has been implicated in both transcription-dependent and transcription-independent apoptosis. Objectives: We aim to interpret the correlation between calcineurin and apoptosis in relation to pathogenesis of breast cancer. Design and methods: Both calcineurin level and activity as well as caspas-3 activity were evaluated in tissue homogenate of 50 breast cancer patients, 20 patients with fibroadenoma and 15 healthy women. Results: Calcineurin activity was significantly low in malignant compared to benign and normal groups (P=0.00) without significant changes in its level (P> 0.05). While caspase-3 showed a significant higher activity in malignant group compared to other groups (P<0.05). Moreover, there was a significant negative correlation between calcineurin activity with grade, stage (P=0.01), caspase-3 (P=0.002) and a significant positive correlation with its level (P=0.039). Conclusion calcineurin activity but not its level has an important role in breast neoplasia, restoration of its normal activity may be act as adjuvant factor of apoptosis and control breast cancer pathogenesis.

Gehan M Nabil is a faculty member in department of chemistry at Alexandria University, Egypt.

The objective of this work is the study of adsorption of the reactive dye RB5 by magnetic iron oxide nanoparticles (NPs) coated with phthalic acid prepared by co-precipitation method. This adsorbent was characterized by scanning electron microscope (SEM), transmission electron microscope (TEM), thermal gravimetric analysis (TGA) and fourier transform infrared (FT-IR) spectra. In batch adsorption procedure variables including the amount of adsorbent, initial dye concentration, contact time, pH and temperature had a great effect on the removal percentage of the dye. The application of magnetite nanoparticles loaded with phthalic acid as an adsorbent of RB5 removal has been successfully tested. The maximum removal percentage is 92% at pH=2, shaking time 20 min., adsorbent dose 25 mg per 10 mgL-1 initial dye concentration at 25°C. Different kinetic models: pseudo-first-order kinetic, pseudo-second-order kinetic, intraparticle and Elovich kinetic models were applied to examine the mechanism of adsorption. The data kinetically followed the pseudo-second-order kinetic model. Equilibrium adsorption capacities were determined by fitting experimental data to isotherm models: Langmuir, Freundlich, Dubinin-Radushkevich isotherm and Temkin models. Based on the calculated thermodynamic parameters ΔG, ΔH and ΔS, it was noticeable that the adsorption was a spontaneous and an endothermic process. The potential application of phthalic acid-loaded magnetite for the adsorptive removal of RB5 dye from real water samples was discussed.

Tugba Ozer has completed her MSc in Marmara University. She is a PhD student in Yildiz Technical University, Department of Bioengineering. Her areas of specialization are: electrochemistry, environmental chemistry, analytical chemistry, heavy metals, sensors, crop science, biopolymer, bioinformatics, systems biology.

A novel iron (II) selective membrane electrode based on 2-cyanomethyl N-methyl-N-phenyl dithiocarbamate and its applications: Iron has a vital role in all living systems including transportation and storage of oxygen, electron transport and production of enzymes. It can be hazardous for health if its concentration has excess level in the body causing liver and kidney damage, irritation in stomach. Also, iron deficiency results in anaemia. There is increasing need to determine iron ion concentration in medicinal, clinical, environmental and industrial samples. Solid contact PVC based membrane electrode provides an alternative platform by eliminating inner reference solution to achieve better response properties such as selectivity, sensitivity, response, pH range, and response time of ISE as well. The effects of different parameters such as the quantity of plasticizer, the type of plasticizer, pH of the sample solution, and coexisting ions on the potentiometric responses of the electrode were investigated. 2-Cyanomethyl N-Methyl-N-Phenyl Dithiocarbamate has strong affinity toward Fe (II) ions and thus it was assigned as an ionophore for designing a Fe2+ selective electrode with a slope of 31.55 mV per decade over a wide concentration range of 1.0 × 10−7− 1.0 × 10−1 M Fe2+. The obtained potential values remains constant between the pH ranges 4.5-7.5. The response time was found to be 25 seconds. The electrode revealed good selectivity for Fe2+ in the presence of different coexisting cations and anions. Detection of Fe (II) ions was successfully carried out in water samples with the proposed electrode.

Abulyaissova L K is an Associate Professor of Chemistry in Faculty of Physical and Analytical Chemistry at the Karagandy State University, Republic of Kazakhstan. She has published more than 70 papers and presentations in both international and national journals and scientific conferences. She is the author/co-author of 2 textbooks and the member of the International Liquid Crystal Society.

The conformational properties of thermotropic 4-alkyl- or 4-alkoxy-4'-cyanobiphenyl have been studied. The substances are in a variety of leading companies producing liquid crystal materials due to the absence of color, low viscosity, stability, low melting temperatures. The geometry of the molecules of 4-n-pentyl-4'-cyanobiphenyl (BP-5), 4-n-pentoxy-4'-cyanobiphenyl (OBP-5), 4-n-octyl-4'-cyanobiphenyl (BP-8) and 4-n-decyl-4'-cyanobiphenyl (BP-10) was optimized by the molecular- mechanical method with force field MM2 and quantum-chemical method B3LYP/6-31G(d). The dependence of the mesomorphic properties of substances and the structural parameters of molecules on the length and nature of the non-rigid fragments has been examined.

Hugo Romero has completed the Master's program in Chemistry at the Catholic University of Valparaiso, Chile. He works as a researcher and Professor at the Faculty of Chemistry at the Technical University of Machala, Ecuador, where he has served as Director of Chemical Research Center and Director of the Center for Technology Development. His research lines are Corrosion and Applied Electrochemistry. He has published about 10 papers in reputed journals such as Progress in Organic Coutings, Talanta, Advances in Chemistry and Analytical Chemistry Research.

The aim of this investigation was to assess the potential of corrosion of ASTM A36 steel specimens means cyanide and thiourea in two different concentrations used in leaching processes, by polarization curves at room temperature (298 K). Furthermore, evaluate the surface state of the accelerated corrosion caused by electrochemical measures of SEM microscopy studies. To develop the experiment was used as research material specimens ASTM A36 steel, obtained from pieces of this material are used in the manufacture of a leaching reactors industry processing plant. Square samples of 2 cm by side and 0.3 cm thick were used. The weight and dimensions necessary to calculate the surface area and the initial value of the weight for the corrosion tests samples and weight loss was determined. As corrosive medium was used cyanide and thiourea industrial grade obtained from a local company. The samples subjected to corrosion tests were analyzed using scanning electron microscopy to observe the characteristics of the surface with a Phenom Pro desktop Scanning electron microscope (SEM). Electrochemical tests were performed with a CH Instruments potentiostat model 700D. The results of the corrosion potential of -0.32 V was for steel in sodium cyanide 0.62 g/l and thiourea -0.47 v to 0.96 g/l. For his part for concentrations of sodium cyanide 0.80 g/L thiourea 1.24 g/L corrosion potentials were -0.34 V and -0.49 V respectively. This allows us to conclude that metal ASTM A36 steel samples have higher corrosivity thiourea solutions compared with solutions of sodium cyanide.

Mu Naushad is currently working as Assistant Professor, Department of Chemistry, King Saud University, Saudi Arabia. He did his Ph.D. degree in Analytical chemistry, A.M.U. Aligarh, India in 2007. He has extensive research experience in multi-disciplinarily fields of Material Science, Analytical Chemistry and Environmental Science. He is the author of more than 45 research articles, seven book chapters and two books of international repute. Moreover, he is the editorial member of more than 30 international journals.

Alizarin red-S modified amberlite IRA-400 resin (ARSA) was applied for Hg2+ removal from the aqueous medium which is highly toxic metal ion. The adsorption process which was pH dependent, showed maximum adsorption of Hg2+ in the pH range 6 to 8. ARSA exhibited good monolayer adsorption capacity for Hg2+ (303.03 mg g-1) at 25C and the isotherm was well fitted by the Langmuir model. Moreover, the adsorption was evaluated thermodynamically and the negative values of ∆Go revealed the spontaneity of adsorption process. The practical applicability of ARSA was explored for the adsorption of Hg2+ metal ion from a real water sample. The values of ΔH and ΔS were found 79.87 kJ mol-1 and 0.26 J mol-1 K-1, respectively.

Nicharat Manmuanpom is a PhD student at Petroleum and Petrochemical College, Chulalongkorn University in major of polymer science. She graduated with Bachelor’s degree from Chulalongkorn University in Department of Chemistry. Much of her work focuses on polybenzoxazine synthesis and its application.

Carbon dioxide capture and storage (CCS) is the technology by which carbon dioxide emissions from power plants are captured and stored for future use. The process could help reduce the greenhouse gas in the atmosphere which is the cause of the climate change. Recently, porous carbons which have micro-mesopores structure, high surface area and high nitrogen sites can enhance the CO2 adsorption capacities because the basic nitrogen groups can interact with CO2 gas. In this study, micro-meso porous carbons with high nitrogen content were prepared from polybenzoxazine as a precursor and silica nanoparticles as a hard template to generate mesoporous structure. Polybenzoxazine, an additional cure phenolic resin is an excellent carbon precursor since the molecules can be easily designed to incorporate nitrogen functional groups without complicated synthesis procedures. The morphology of carbons was investigated by FE-SEM. The Autosorp 1-MP carried out to determine the surface area, particle size and pore volume of the resulting nanoporous carbon. The effect of pyrolysis temperature to obtain nitrogen enriched nanoporous carbon was confirmed by using XPS and elemental analyzers. As a result, activated carbon that using 40%wt. silica colloidal template and pyrolyzed at 800°C exhibited high CO2 uptake (1.233 mmol/g at 30ºC, 1 bar). The adsorption of CO2 was increased because the pyridine and pyridone types of nitrogen reacted with CO2 gas, as well as physical adsorption of the micro-meso porous structure.

Wei Zhe Teo is a faculty member in Nanyang Technological University, School of Physical and Mathematical Sciences, Division of Chemistry & Biological Chemistry, Singapore.

With the advances in nanotechnology over the past decade, consumer products are increasingly being incorporated with carbon nanotubes (CNTs). As the harmful effects of CNTs are suggested to be primarily due to the bioavailable amounts of metallic impurities, it is vital to detect and quantify these species using sensitive and facile methods. Therefore, in this study, we investigated the possibility of quantifying the amount of redox-available iron-containing impurities in CNTs with voltammetric techniques such as cyclic voltammetry. We examined the electrochemistry of Fe3O4 nanoparticles in phosphate buffer solution and discovered that its electrochemical behavior could be affected by pH of the electrolyte. By utilizing the unique redox reaction between the iron and phosphate species, the redox available iron content in CNTs was determined successfully using voltammetry.

Roberta Romano graduated cum laude in Biotechnological Sciences at University of Salento in 2012. She worked as external collaborator for Eggplant srl, conducting her research in the production and green-recovery of PHB from olive mill wastewater using Azotobacter vinelandii. This activity was published in the Journal of Life Sciences with the title “Complete valorization of Olive Mill Wastewater through an integrated process for poly-3-hydroxybutyrate production”. She also conducted research at the Laboratory of Biochemistry and Microbiology of the University of Salento and worked in the Del Giudice’s lab of the University of Naples analyzing the properties of various sorghum hybrids.

Sorghum is one of a major crop used for food, feed and industrial purposes worldwide. As such it has the potential to be a valuable source of biomaterials. Kafirin, the storage protein of sorghum, can form biodegradable plastic films. However, producing the plastic from sorghum protein could be very expensive and time consuming. A cheaper alternative would be to produce biodegradable plastics from starch present in the bran of sorghum grains. Over the last years the environmental impact of plastic waste on the ecosystems represents a critical problem. Bacterial poly-3-hydroxybutyrate (PHB) is an ecological alternative. Food industry waste represents a sustainable medium for bacterial growth and PHB production. We are interested in producing PHB by bacteria grown in the presence of sorghum bran. Our preliminary studies focused on the use of the bran of sorghum hybrids grown in South of Italy as medium for Sphingomonas cynarae cells in order to produce PHB. The mean composition of these brans consisted of about 28% starch, 14% protein and 3% fat. The bran powder was resuspended in water (1:10 w/v) and autoclaved to make available the starch. Primarily, we detected the amylase activity of S. cynarae by plating methods. Transmission electron microscopy (TEM) analysis has confirmed the PHB accumulation in the cells and it was recovered by high pressure homogenization. The yield was approximately of 0.6 g/L. To our knowledge, this is the first report describing the production and green-recovery of PHB by S. cynarae utilizing sorghum bran as a nutritional source.

Sevil Çetinkaya is a Professor of Inorganic Chemistry in the Department of Chemistry at Kirikkale University. She obtained her PhD in Inorganic Chemistry at Hacettepe University in 2003. She was a TÜBİTAK/Royal Society visiting Research Fellow at Durham University in 2005. She received L´Oréal Turkey for Young Woman in Science Award in 2016. She joined the Kirikkale University as an Assistant Professor in 2006, and became an full Professor in 2013. Her current research interests focused on organometallic chemistry, design, preparation and applications of nanomaterials and porous carbon materials.

Nanostructured oxides are gaining continuous importance for various applications due to their unique physical and chemical properties based on the size-homogeneity and large specific surface area. Crystallography and size of the nano-materials greatly affect their applications in designing optical, electronic, magnetic and catalytic materials. NiO is an important inorganic oxide extensively used in catalysis, battery cathodes, electrochromic films, and magnetic materials. Nanocrystalline NiO is believed to have many better properties than those of micrometer-sized NiO particles in terms of the volume effect, the quantum size effect, the surface effect. The present work represents an attempt to synthesize of suitable NiO-nanoparticle for the design of high performance novel nanocomposite materials. The effect of synthesis conditions on morphology development and surface area was experimentally investigated. Nano-NiO particles have been obtained by thermal decomposition method using NiCl2 and NH3.H2O as the raw materials. After calcination process of the Ni(OH)2 precursors at 400-500°C for 1 h, green Ni(OH)2 precursors have been transformed into black NiO nanoparticles. XRD patterns of NiO nanoparticles confirmed the conversion of Ni(OH)2 into NiO nanostructure. Nanostructures were also confirmed SEM, TEM, FTIR, Raman and Uv-vis analyses. Analysis results reveal that the synthesized nanoparticles have cubic particles with an average diameter of around 8-13 nm. The NiO nanoparticle obtained at 400°C with the highest surface area and small crystal size has been chosen as a suitable dopant to design new nanocomposite materials.

Alena Tomšik is a PhD student at Department of Biotechnology and Pharmaceutical Engineering, Faculty of Technology, University of Novi Sad. Currently, she is employed as a research associated at Institute of Food Technology, University of Novi Sad.

Allium species have been used as a source of health benefit compounds in the traditional medicine for many centuries thanks to its wide-spread distribution and popularity as edible and medicinal plant. In the past few years the interest for wild garlic and its use for prevention, maintaining of the human health as well in nutrition is significantly growing. Subcritical water extraction, SWE, is recognized as one of the most potential extraction technologies for isolation of bioactive compounds, especially antioxidants. Therefore, optimization of subcritical water extraction was conducted in order to maximize antioxidant capacity of the extract. Antioxidant capacity was investigated by application of two test analysis, DPPH and ABTS test. The antioxidant activity for obtained A. ursinum extracts determined using DPPH test, was in the range from 0.04 to 0.47 mg/ml (calculated on IC50), while antioxidant activity measured by ABTS ranged from 0.96 to 11.78 mM TEX/100g DW. Additionaly total phenols and flavonoides were analyized which are responsile for antioxidant activity. Temperature shows to be the most important extraction parameter. The increase of temperature induces the increase of antioxidant activity of obtained extracts (expressed in DPPH and ABTS test). Antioxidant activity of extracts obtained using subcritical water extraction was much higher than activity of A. ursinum extracts obtained in our previous study.

Sevinc Ilkar Erdagi continues her PhD in Kocaeli University, Turkey under supervisior of Prof. Dr. Cavit Uyanik. She is a Research Assistant in Kocaeli Univeristy for five years. She studies organic chemistry especially in steroid chemistry and natural products.

Aphidicolin is a diterpene and possesses a 1,2-glycol at C-16;C-17 and a 1,3-glycol at C-3;C-18. It is a specific inhibitor of DNA polymerase-α and has attracted much interest because of potentially useful level of antitumor activity. In this study we describe the synthesis of 13α-methyl and 13β-methyl steroids in which the functional groups associated with the biological activity of the tumour inhibitor, aphidicolin have been introduced onto the steroid backbone in order to attempt to combine the biological activity of the two classes of compound. The steroids possess a characteristic tetracarbocyclic carbon skeleton. The viridin family of steroidal antibiotics have a furan ring between rings A and B. These compounds have been named systematically as furanosteroids. Recent synthetic and biological studies of the viridin class of steroidal furans have revealed multiple opportunities for fundamental discoveries as well as advanced drug design. In this study we also describe attempts to construct a furan or a tetrahydrofuran ring between rings A and B of cholesterol.

Ulisses Fiorin Angelo completed his chemistry degree from the University of São Paulo, his Masters degree, and currently, he is on course of the last period of his Doctoral studies in Molecular Materials and Interfaces Laboratory (MMIL) (http://sites.usp.br/lmim/) at the same University. He is a member of the Editorial Board of “CADERNOS CIMEAC”, a periodic specialized in popular education.

Naphthalic imides are usually fluorescent molecules, obtained by the reaction of 1,8-naphthalene anhydrides and primary amines. This class of compounds is interesting due to a series of chemical and physical properties such as chemical and thermal stability, well defined and scaleable (by aromatic rings functionalization) spectroscopy and electrochemical properties as they are also electron acceptors, allowing them to mediate electron transfer processes. These molecules are generally solvatochromic and photoactive towards photoinduced eletron transfer, and they may be used in optical sensors. Due to this property, they behave like n-type semiconductors in solid state, allowing the construction of electronic devices like transistors and OLEDs too. They undergo reversible redox reactions at modest potential forming stable radical anions easily identified by (EPR). Bidentate naphthalimides, as 4-amino-N-4-pyridin-1,8-naphthalimide are also regarded as bridging ligands to prepare “Metal-organic Frameworks” (MOFs) whose properties and structure can be modulated by changing its substituents. 4-amino-N-4-pyridin-1,8-naphthalimide was synthesized for the first time, by the reaction between 4-nitro-1,8-naphthalic anhydride and 4-aminopyridine on ethanol reflux. The imide reduced on a stannous chloride acidic solution and purified by the recrystallization on methanol. High fluorescence was observed in organic solutions. Its structure was elucidated by NMR. Emission and absorption spectra were studied in different solvents and at several pHs, in aqueous solutions. We have noticed decreasing intensities of fluorescence spectra as well as a small bathochromic shift, as the polarity of solvent increases. Changing medium´s acidity, (pH range between 2.04 and 5.60) it was possible to indentify two pKa values (2.75 and 3.49) as predicted by theoretical calculations, using absorption data. We could also observe what seems to be an hypochromic shift as the pH increases, but this has to be confirmed by other measurements such as quantum yield, and excited-state lifetime.

Tuanta Sematong has completed her degree from Chankasem Rajabhat University. Her excellent experience in Pharmaceutical and natural products safety evaluation as well as efficiency and safety of herbal products development and standardization for more than 30 years at Pharmaceutical and natural products department, Thailand institute of Scientific and Technological Research (TISTR), Thailand. Besides, her great specialize in animal model experimentation has supported SMEs, pharmaceutical companies and private sectors for products evaluation.

The peptide was extracted by using alkaline from Pigeon pea (Cajanus cajan (L) Millsp). This work aimed to study antioxidant activity of peptide using in cosmetics. Antioxidant activities were measured by using DPPH assay, compared to ascorbic acid. The IC50 value of peptide extracts were 61 µg/ml, considered higher than that in ascorbic acid (IC50= 1.37 µg/ml). Whereas the inhibition on dopa oxidase activities of mushroom tyrosinase were (IC50) 41 µg/ml which were weaker than arbutin (IC50 = 1.91 µg/ml). The stimulating effect of dermal fibroblasts (ATCC CRL-1474) on collagen type I synthesis were evaluated by the ELISA test kit. The peptide extracts resulted in the highest activity for stimulating collagen type I synthesis. The activities at concentration of 200 µg/ml were found in the range of 59.34±2.17. This effect was nearly the same ascorbic acid (59.51±3.17%) at concentration of 50 µg/ml. The anti-wrinkle and anti-melasma were evaluated for 8 weeks which subjected on 22 ±2 of Healthy Asian skin type female with their age between 35-65 years old. The anti-melasma was tested by using chromametry technique, the solution of 0.2 % peptide was able to significantly lighten the treated melasma after 8 weeks. Skin replica with Shadow casting analysis for anti-wrinkle effect on the crow’feet area, was significantly decreased the number of wrinkles (-11.0 of -17.4 %, p<0.01), and mean depth (-9.1µm or -8.9 %, p<0.05). The results showed that the peptides were extracted with alkaline from Pigeon pea were suitable as active ingredients in cosmetics.

Vesile Şima Ünnü is currently a MSc student in the Department of Chemistry at Kirikkale University (Turkey). In 2015, she graduated from the Kirikkale University with first-rank honours in chemistry. She is working on a research project as a scholar. Her research interest focuses on the design of porous polymers and new metathesis catalysts.

PolyHIPE is a porous polymer produced by polymerization of the continuous phase in a two phase system. The cell size and surface area of polyHIPE materials are strongly affected by the amount of surfactant and type of inert porogen. Our previous studies has shown that porous polyHIPE can be used as a support material for the design of metathesis catalyst. The work presented here describes some of our recent results as part of our programme of work aimed at preparing polyHIPEs having high-surface area synthesized from divinylbenzene to be used as support for the preparation of new generation metathesis catalyst. Effects of triple surfactants ratio and porogen type on the properties of the polyHIPE were studied to select a suitable condition for preparation. Stable w/o HIPEs were prepared using mixtures of different amounts of cationic surfactant cetyltrimethylammonium bromide, anionic surfactant sodium dodecylbenzenesulfonate and nonionic surfactant sorbitan monolaurate (SPAN 20) for investigating the effect of surfactant type. PolyHIPE samples were synthesized by the polymerization of the continuous phase of w/o high internal phase emulsions. The effect of surfactant concentration on the morphologies of polyHIPEs was investigated by scanning electron microscopy and BET. Increasing the amount of cationic surfactant from 0.3% to 0.9% led to an increase in surface area while increasing the amount of anionic surfactant from 0.3% to 0.9% led to a decrease in surface area in the resulting porous materials. The presence of 1,2-dichlorobenzene instead of toluene or chlorobenzene as a porogenic solvent in the oil phase was found to increase the cell size and surface area remarkably. This work has been supported by Kirikkale University Scientific Research Projects Coordination Unit (Turkey) (Project No. 2015/70).

Sang Jun Lee received his BS degree in Chemistry at Kwangwoon University in 2016. Currently, he is studying for his MS degree in chemistry at Kwangwoon University. His current research interests are mainly in the development of polymer chemistry under Professor In Tae Kim.

In this study, we investigated the interactions between the ionic liquids (ILs) of ammonium and imidazolium families and polyaniline–emeraldine base [PANI (EB)]. PANI (EB) is one of the most studied conducting polymers owing to its applications in electronics, optical devices, sensors, etc. However, there is a massive scope of improvement in this area. In order to increase the utility of PANI (EB), we studied the interactions between PANI (EB) and ILs by using various techniques. Further, we studied the conductivity, morphology, and roughness of PANI (EB)–IL mixtures. We observed that ammonium- and imidazolium-family ILs have the potential to interact with PANI (EB). However, after the interactions, the ammonium-family IL–PANI (EB) mixtures showed more conductivity than the imidazolium-family IL–PANI (EB) mixtures. We also determined the strength of hydrogen bonding between ILs and PANI (EB) from semiempirical calculations carried out using HyperChem 7. Finally, we demonstrated that PANI (EB)–IL additives can be used as electrolytes in dye-sensitized solar cells. This study provides an insight into the combined effect of a polymer [PANI (EB)] and ILs, and this insight may generate many theoretical and experimental opportunities.

Dapeng Wei has completed his PhD from Peking University and Postdoctoral studies from Purdue University. Now, He works as a Professor at Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences. He has published more than 30 papers in reputed journals and His research interest is foucsed on the synthesis of graphene or other 2D materials.

Graphene is regard as one of the most promising candidate material for future electronics. In fact, graphene film, deposited on metal catalyst via CVD process, normally has poly-crystalline structures and need to be transferred onto a dielectric surface for photoelectrical applications. The transfer process usually induces contaminations, winkles or even breakage of graphene, which hamper the practical applications of graphene in electronics. Annealing is a simple and feasible approach to tailor the electrical properties of intrinsic graphene. Meanwhile, thermal treatment of graphene could recombine the poly-crystal structures, burn off the contaminations and strengthen the adhesion of graphene and substrates. However, few studies focus on the influences of annealing atmosphere on graphene transparent electrode, that is, whether the thermal gas causes any changes in graphene intrinsic photoelectric performances. Here, we investigated the effects of annealing atmosphere, and developed a simple and effective approach to improve photoelectric properties of pristine graphene via an air-annealing process. In contrast to PGs, the mobility and carrier concentration of air-annealing graphene films (AAGs) were significantly enhanced. Thedele resistance was greatly reduced by more than 30 percent. At the same time, the air-annealing process has also promoted the transparency of PGs by about 3%. Importantly, the as-improved photoelectric properties of AAGs were extraordinarily stable, and the transmittance and resistance remained almost no changes when repeating the same measurements after 100 days. This stable enhancement method provides a simple pretreatment approach for the practical application of graphene transparent electrode.

Jiyoon Kwon is from Chemical Sensor Research Group, Department of Chemistry, Kwangwoon University, Korea.

A number of patients who complain of laryngopharyngeal reflux disease (LPR) is on the gradual increase due to changes in climate and environment. LPR causes hoarseness, frequent throat clearing, bitter taste in the mouth, referred ear pain, chronic cough and even larynx cancer. However, the effective treatment of LPR is difficult because the treatment yet stay in the inhibition of gastric acid secretion as well as the symptoms persist after treatment. Therefore, appropriate treatment through accurate and rapid diagnosis is necessary. Since pepsin is proteolytic enzyme produced only in the stomach, detection techniques of pepsin in saliva is useful as a sensitive and non-invasive method for the reflux of stomach contents. Therefore, pepsin is one of the most important biomarkers to diagnose LPR. Herein, we report on a new approach to design an immunoassay based lateral flow immunochromatographic assay for the rapid detection of pepsin. The strip consisted of four main components: sample pad, conjugate pad, membrane and absorbent pad. Nitrocellulose membrane was separately coated with goat anti-rabbit antibodies (control line) and monoclonal anti-pepsin antibodies (test line). The detector reagent consisted of gold nanoparticles coated with polyclonal anti-pepsin antibodies, which saturated the conjugated pad. When pepsin-containing samples were applied to the sample pad, the antigen initially reacted with polyclonal antibody-coated gold nanoparticles and then reacted with the fixed monoclonal antibody on the membrane. These reactions resulted in red line at the test line, with intensity proportional to the pepsin concentration. In this ways, we investigate the utility of lateral immunoassay to determine pepsin in biological samples (i.e., saliva).

Silvia Antonia Brandán is a Faculty Biochemistry, Chemistry and Pharmacy, in Inorganic Chemistry Institute, University National of Tucumán (UNT), Tucumán, Argentina. She is Graduated in Chemistry (UNT); Chemical Engineer (UNT); PhD in Chemistry (UNT); Post-Doctorate in Alicante University, Spain. She is the Titular Professor of General Chemistry and Director of the Inorganic Chemistry Institute. She is the Editor Journal of Molecular Structure.

In this work, the influence of the different S=O, S-O, NH, OH, NaO bonds present in the structures of the powerful laxative drug, sodium picosulphate in gas and aqueous solution phases were studied combining the density functional theory (DFT) calculations with the experimental available infrared, 1H-NMR and UV-visible spectra. The structural, topological, electronic and vibrational properties were investigated in both media by using the hybrid B3LYP/6-31G* method and the integral equation formalism variant polarised continuum model (IEFPCM). Here, the characteristics of the S=O, S-O, NH, OH, NaO bonds were completely revealed by using atomic charges, natural bond orbital (NBO) and atoms in molecules (AIM) studies. The infrared, 1H-NMR, 13C-NMR and UV-visible spectra are in reasonable concordance with those experimental available in the literature. The following reactivity order it is observed when picosulphate is compared with other potential antimicrobial and antiviral drugs: thione > brincidofovir > sodium picosulfate > thiol > cidofovir. The vibrational analysis of sodium picosulphate was performed considering C3V symmetries for both SO42- groups and the complete assignments of the 126 vibration modes were reported in gas phase and aqueous solution together with their corresponding force fields. In addition, the reactivities of sodium picosulfate increase in solution due to their ionic characteristic which probably justifies their behaviour as a stimulant cathartic and their easy metabolic conversion, as reported in the literature.

Ramón Aznar is a professional Agronomist Engineer with two MSc and more than 5 years of experience working in laboratories in Ireland, Italy and Spain, developing a good knowledge in environmental chemistry. Currently, he is at the edge of his PhD at INIA (fellowship grant, RTA2014-00012-C03-01). He has published more than 6 papers in international journals and is looking forward to have new challenges after finishing his PhD.

Spreading poultry manure as fertilizer on agricultural fields has been promoted by national authorities as an economic way of recycling. However, poultry manure may contain contaminants, which could be incorporated into crops and be distributed in the environment. Among the different types of contaminants, emerging contaminants and particularly pharmaceutical compounds are rising concern due to their presence in different environmental matrices. In this work, an analytical method was developed for the simultaneous determination in poultry manure of 12 pharmaceutical compounds (acid, neutral or basic) belonging to different families (nonsteroidal anti-inflamatory drugs and analgesics among others). These compounds were extracted with acetonitrile by ultrasound assisted matrix solid phase dispersion in tree steps at different pHs and then purified with C18. The compounds were determined by gas chromatography with electron impact mass spectrometric detection in the selected ion monitoring mode (GC-MS-SIM), using matix matched standards to contra rest the matrix effect. Recoveries from spiked samples at tree levels (150, 75 and 25 ng g-1) were ≥ 70 % for most of the compounds with relative standard deviations ≤ 12 %. The limits of detection and quantification ranged from 0.8 to 2.8 ng g-1 and 3.0 to 9.3 ng g-1, respectively. The response obtained with this method was linear over the range assayed (0 to 500 ng g-1), with correlation coefficients ≥ 0.997. The validated method was applied to samples collected from different farms in Spain where salicylic acid was commonly found.

Seong-Hyun, Kim received BS degrees in Mechanical Engineering from HOWON University in 2010 and MS degrees in Mechanical Engineering from INHA University in 2012. He is currently a PhD candidate at the Graduate School of Mechanical Engineering at INHA University in Incheon, Korea. His research fields are in micromachining by using chemical reaction, electro-chemical manufacturing and the development of a ultra-precision machining system.

Electro-chemical machining appears to be one of the rather promising micro-machining techniques in many fields. It offers some of advantages including higher machining rate, no tool wear and better precision. Recently, many researches have investigated on special alloys. Invar alloy which is widely used in many industries such as aircraft, frontier display's shadow mask such as OLED, mobile display, biotechnology and aerospace has been applied in this study. Invar is a compound metal of Fe-Ni system and contain 36% Ni. The most distinction characteristic of Invar is the coefficient of thermal expansion is 1.0×10-6cm/℃. Its coefficient of expansion is a very low. Generally, when neutral solutions are used for electro-chemical machining of Invar alloy, debris are produced and stay between electrode and workpiece. It causes the stains on invar alloy and decrease the accuracy. In case of using acid solutions for electro-chemical machining on Invar alloy, there is no debris during the process. But, acid solution reacts with Fe ion in Invar alloy. For this reason, the corrosion is generated on the surface of Invar alloy. In this study, focused mixed electrolyte consists of eydrogen peroxide, acetic acid and sulfuric acid. The performance of each of solutions for electroc-hemical machining has been analyzed. Based on the study, the machinability is compared with each concentration and each solution. Therefore, ions in electrolyte are involved in the electro-chemical machining process to affect machinability characteristic.

A M Prodan is a young surgeon with a PhD and a postdoc fellowship in Chemical Engineering. Also, she is a PhD student in Medicine at Carol Davila University of Medicine and Pharmacy. Moreover, she is involved in research activities involving materials with biomedical applications. She is a co-author of more than 10 relevant papers in her field of work.

Synthetic hydroxyapatite (HAp) was studied in the last decades due to its crystallographical and chemical resemblance with the mineral part of the human hard tissue. It was proven that HAp has the ability to bond directly with bone tissue. Recently, HAp was used extensively as a coating material in orthopaedic and orthodontic surgeries. In order to enhance the biocompatibility of HAp, researchers tried to dope it with divalent cations. Silver is well known for its microbiostatic and microbicidal properties. The size and dose of silver nanoparticles strongly influence the antimicrobial properties. Considering that the organic componet of bone tissue is collagen, researcher tried to combine the unique properties of hydroxyapatite, collagen and silver in order to obtain new biomaterials with improved properties with possible application in medicine. The aim of this study was to characterize the properties of collagen/silver doped hydroxyapatite composites (Coll/Ag:HAp). The Ag:HAp powders were obtained by co-precipitation method and Coll/Ag:HAp were obtained in agreement with previous studies. The obtained composites were investigated by XRD, showing that the structure of the sample belongs to hexagonal hydroxyapatite. The morphological studies revealead that the morphology of the composite is influenced by the precence of Ag. The antimicrobial activity of Coll/Ag:HAp composite angainst S. aureus and P. stuartii was evaluated, showing an efficient antibacterial activity against them. Antibacterial activity increased with the increase of Ag concentration in the samples. Our results suggest that Coll/Ag:HAp composite could be used in many biomedical applications.

A M Prodan is a young surgeon with a PhD and a postdoc fellowship in Chemical Engineering. Also, she is a PhD student in Medicine at Carol Davila University of Medicine and Pharmacy. Moreover, she is involved in research activities involving materials with biomedical applications. She is a co-author of more than 10 relevant papers in her field of work.

Synthetic hydroxyapatite (HAp) was studied in the last decades due to its crystallographical and chemical resemblance with the mineral part of the human hard tissue. It was proven that HAp has the ability to bond directly with bone tissue. Recently, HAp was used extensively as a coating material in orthopaedic and orthodontic surgeries. In order to enhance the biocompatibility of HAp, researchers tried to dope it with divalent cations. Silver is well known for its microbiostatic and microbicidal properties. The size and dose of silver nanoparticles strongly influence the antimicrobial properties. Considering that the organic componet of bone tissue is collagen, researcher tried to combine the unique properties of hydroxyapatite, collagen and silver in order to obtain new biomaterials with improved properties with possible application in medicine. The aim of this study was to characterize the properties of collagen/silver doped hydroxyapatite composites (Coll/Ag:HAp). The Ag:HAp powders were obtained by co-precipitation method and Coll/Ag:HAp were obtained in agreement with previous studies. The obtained composites were investigated by XRD, showing that the structure of the sample belongs to hexagonal hydroxyapatite. The morphological studies revealead that the morphology of the composite is influenced by the precence of Ag. The antimicrobial activity of Coll/Ag:HAp composite angainst S. aureus and P. stuartii was evaluated, showing an efficient antibacterial activity against them. Antibacterial activity increased with the increase of Ag concentration in the samples. Our results suggest that Coll/Ag:HAp composite could be used in many biomedical applications.

Reza Pashaei is a student of Master of Chemistry at Siena University. Mortaza Gholizadeh is a Post doctoral student at Curtin University. He published more than 10 ISI articles.

Nitrogen is the most important gas in nature because of some reasons. Nitrogen is the vital source for providing food for organisms and microorganisms. Providing this prominent source need to cycle for transferring the nitrogen for all the organisms in nature namely plants and animals in water and soil that this cycle called nitrogen cycle. This article mention to nitrogen cycle role in air, soil, and water.

Asuka Namai is currently an Assistant Professor of Department of Chemistry, School of Science at The University of Tokyo. She received her PhD. in Science at the University of Tokyo, Japan, in 2013. Her research focuses on the development and physical and chemical characterization of functionalized nanomaterials, with particular interest in iron oxide-based nanomagnets and magnetism.

Epsilon-iron oxide (ε-Fe2O3) is one of the polymorphys of Fe2O3, which exists as a stable phase in nanometer-size ~ sub-micrometer-size region.[1] ε-Fe2O3 receives much attention as a hard mangeitc ferrite, since it exhibits the largest coercive field (Hc > 20 kOe) among magnetic ferrites. In addition, it shows a high frequency millimeter wave absorption at 182 GHz due to zero-field ferromagnetic resonance.[2] Herein, we report the synthesis, magnetic properties, and millimeter wave absorption properties of metal substituted ε-Fe2O3 nanomagnets.[2,3] A series of -MxFe2-xO3 (M= Al, Ga, In, and Rh) were prepared by several nanoparticle synthesis methods, such as a combining method between a reverse-micelle and a sol-gel methods. Crystal structure analyses based on X-ray diffraction pattern indicate that subsistution site differs between substitution metal. Among four non-equivalent sites in -Fe2O3 (FeA, FeB, FeC, and FeD), In3+ substitutes distorted octahedral FeA and FeB sites, Rh3+ substitutes regular octahedral FeC sites, and Al3+ and Ga3+ substitute tetrahedral FeD sites, which can be understood by the difference of ionic radii. Magnetic properties are also affected by metal substitution. The Hc value is reduced with Al3+, Ga3+, In3+ substitution from 20 kOe to 2 kOe, but Hc value is enlarged by Rh3+ substitution and a large Hc value of 31 kOe was observed. Millimeter wave absorption frequency decreased from 182 GHz (ε-Fe2O3) to 35 GHz by Al3+, Ga3+, In3+ subsutitution, but increased up to 222 GHz by Rh3+ substitution. Such a largely tunable magnetic property and millimeter wave absorption property of ε-Fe2O3 is useful from the viewpoint of material design.

Valentin Karabelyov has completed his secondary education in 2013 from National High School of Maths and Science. Now he is studing in the Medical University of Sofia, Faculty of Pharmacy. He works as an assistant in a pharmacy from 2 years ago. He is interested in the fields of LC-MS, Mass secondary education, Bioanalysis, Chemical synthesis, Pharmacognosy and Medpharmacyicinal chemistry.

Several 2H-chromene and coumarin based hydrazones were synthesized and evaluated for their anticonvulsant activity and neurotoxicity. The structures of the newly synthesized compounds were confirmed by 1H and 13C NMR, FTIR and HRMS (ESI) spectroscopy. The initial anticonvulsant screening was performed using the maximal electroshock induced seizure tests (MES) and the subcutaneous pentylenetetrazol (scPTZ) test in ICR mice. All 2H-chromene (3a,b) and coumarin (3c,d) based hydrazones demonstrated potency in at least one seizure test. Among all the tested compounds, only 3b showed activity at the lowest dose of 30 mg/kg, which was comparable with the referent drug phenytoin, while compounds 3a and 3d suppressed tonic-clonic seizures in the MES test at the highest dose of 300 mg/kg. All agents demonstrated anticonvulsant effect at 0.5 h whereas 3c and 3d in both time points. No neurotoxicity of the tested agents was observed at the doses with activity in this test. Compound 3c was potent at 100 mg/kg, while the compounds 3a and 3d protected against clonic seizures at the highest dose of 300 mg/kg in the scPTZ test. This activity was shown at time interval of 0.5 h and lacked neurotoxicity compared to DZP showing an activity at the lowest dose of 30 mg/kg. Taken together, the results suggest that the newly synthesized 2H-chromene and coumarin based benzoylhydrazones could be efficient as adjuvants against secondarily generalized tonic-clonic seizures and primarily generalized seizures in humans.

Wooseop Lee has achieved Bachelor’s degree of Chemical Engineering in year 2015 from Yonsei University, Korea. He is now studying in graduate school of Yonsei University, the chemical and biomolecular engineering department. His research is closely related to examining the fundamental properties of polymer brush and BCPs, and its application for the advanced materials.

Perpendicular orientation of block copolymer(BCP) thin film has advantage of achieving uniformly well-defined nanopattern. In this study, polystyrene-b-poly(methyl methacrylates) (PS-b-PMMAs) with various molecular weights were utilized to investigate the effect of film thickness on the in-plane ordering, which was assessed via defect distance (D) and orientational correlational length(ξ) analysis to derive the power law relationships versus film thickness. The perpendicular orientation of BCP thin film was facilitated by the surface energy neutralization by hydroxyl-terminated random copolymer, PS-r-PMMA. Thin film morphology was verified by AFM (Atomic Force Microscope), SEM (Scanning Electron Microscope) and GISAXS (Grazing Incidence Small Angle X-ray Scattering). As a result, the PS-b-PMMA with molecular weight higher than 74 kg/mol exhibited the behavior that the lateral ordering was enhanced(D and ξ increased) as the film thickness increases. Whereas in the case of 50 kg/mol BCP film exhibited the tendency that the lateral ordering was enhanced as the film thickness decreases. This research provides an comprehensive guide to understand the thickness-dependent long-range ordering enhancement in BCP thin films.

Sungmin Park received a BS in Chemical & Biomolecular Engineering at Yonsei University, Korea, in 2011. He is currently a PhD student at Yonsei University. His research interests include the self-assembly and phase transition behavior of block copolymer in thin films.

Phase transition behavior and self-assembly of block copolymer (BCP) have attracted much attention in material science and engineering, due to the periodic nanoarrays providing the platforms with various morphologies. BCP film is confined on the substrate, uaually in thin film geometry, the phase transitions would be altered from those of the bulk, more than likely because the ordering and microdomain orientation are appreciably influenced by the interfaces at air/polymer and polymer/substrate, and commensurability of film thickness to the equilibrium period. In this study, the phase transition of an asymmetric polystyrene-b-poly(2-vinylpyridine) (PS-b-P2VP) with the minor PS block was investigated by grazing incidence small-Angle x-ray scattering (GISAXS) and transmission electron microscopy (TEM), particularly in the films subjected under the strong interfacial interactions. The resulting transitions in film geometry were dramatically changed with decreasing thickness due to the growing preferential interactions from the substrate. A thickness-dependent transition diagram exhibited a hexagonally modulated layer (HML) as a stable structure that was extended over the entire temperature range.

Seongjun, Jo has completed his undergraduate course in 2015 from Chungnam National University, Korea and is currently studying for his combined PhD program in Yonsei University, Korea.

Polymer brushes using end-functionality were studied for modifying the substrate to control interfacial interactions between the substrate and melt polymer layer. Interfacial interaction is a critical parameter for polymer thin film system, which determines the thermal and physical properties of polymer films. With the different chemical structures of modified polymer brushes, the thermal dynamics of polymer films dynamically change, such as adhesion, lubrication, slip, and the wettability. Interestingly, the interfacial energy of grafted substrates with polymer chains are remarkably altered by simply controlling the grafting density, which has been referred to as autophobicity. In this study, we controlled the molecular weight of hydroxyl-functionalized polystyrene (HO-PS) to modify the surface on a standard Si wafer. Grafting HO-PSs to a native oxide layer was performed simply by thermal annealing, followed by rinsing with toluene to thoroughly remove the un attached (or unreacted) polymer chains. Deutrated polystyrene (dPS) was prepared on the PS brush layer to develop the neutron contrast between the brush layer and top polymer films, and the double-layed films were subjected to Neutron Reflectivity (NR) experiments. Interfacial penetration and autophobicity will be discussed to characterize the interface between the PS brush layer and top dPS polymer films.

Bongsu Kim has completed his bachelor degree at the age of 26 years from An-dong University School and now he has been studying for master degree from Chung-Ang University School of seoul. While His major is solid chemistry. He focus on the study about new materals of Non-Centro Symmetric(NCS) and Metal-Organic Frameworks(MOFs).

Single crystals and pure polycrystalline samples of new alkali metal niobium selenites have been prepared through hydrothermal and standard solid-state reaction techniques. Single crystal X-ray diffraction was used to determine crystal structures of all four materials. While NaNbO(SeO3)2 is configured with corner-shared zigzag chains of NbO6 octahedra and SeO3 intrachain connectors, three isostructural ANbO(SeO3)2 (A = K, Rb, and Cs) exhibit a layered structure that is composed of distorted NbO6 octahedra and SeO3 polyhedra. Detailed structureal analysis suggests that the size and the coordination environment of alkali metal cations particularly affect the backbone geometries and the dimensions of this materials. Full characterizations including X-ray diffraction, Scanning Electron Microscopy (SEM), infrared and UV-Vis diffuse reflectance spectroscopies, thermal analyses, and dipole moment calculations for the new alkali metal niobium selenites will be presented. Moreover, The future plan about similar compounds using Te4+ ;ANbO(TeO3)2 (A = Na, K, Rb, and Cs) will be described.

Jo Hongil has completed his bachelor degree at the age of 26 years from Chung-Ang University and pursues his combined master’s and doctorate program at Chung-Ang University. He is studying solid chemistry and advised by Prof. Ok Kang Min. He has published 3 papers in reputed journals.

Functional oxides have attracted attention owing to their various applications in electronics, catalyst and optical devices with superior thermal stability. One of them, noncentosymmetric (NCS) oxides have been studied by plenty of research group because they have diverse properties such as pyroelectricity, ferroelectricity, piezoelectricity and nonlinear optical properties at the same time. Thus, several strategies for synthesizing novel NCS materials have been continuously proposed. In this research, we successfully synthesized two novel NCS materials by combining Second-Order Jahn-Teller (SOJT) distortive d0 cations, lone pair cations, and polar displacive d10 cations, i.e, Mo6+, Sb3+, and Zn2+ (or Cd2+). Two new molybdenum antimonites have been synthesized by hydrothermal and standard solid state reactions. The ZnMoSb2O¬7 crystallizes polar space group P21 along with three-dimensional framework composed of MoO4, SbO4, and ZnO4 polyhedra. While CdMoSb4O¬10 crystallizes nonpolar centrosymmetric space group P21/m along with one-dimensional framework consisting of MoO4, SbO3, and CdO6 polyhedra. For ZnMoSb2O7, structural analysis suggests that it has a net polarization in the [0-10] direction due to parellel alignment of MoO¬4 distorted tetrahedra. Local dipole moment calculation is consistent with structural analysis. The result of synthetic experiments for ZnMoSb4O10 and CdMoSb2O7 show that the size of d10 cation affect stoichiometry as well as symmetry. The two molybdenum antimonites were also fully characterized by powder X-ray diffraction, IR spectroscopy, UV-vis spectroscopy, and powder second-harmonic generation measurements.

Dr. Dzhevaga Natalia Vladimirovna completed her PhD in physical chemistry in 2012 from National mineral resources university. Since then, successfully engaged in scientific research in the field of removal of rare earth metals from dilute solutions by flotation and extraction methods. Published more than 70 papers on this topic, including more than 15 articles in journals indexed in international databases. received eight patents on inventions.

The investigation consists in applying the methods of removal rare earth metals from low concentrated solutions by adsorption and extraction methods. The benefits of these methods before the existing analogues are being able to selectively target component removal from dilute solutions and use common surfactants. For the decision of tasks of scientific research is proposed as a surfactant, sodium dodecyl sulfate. Salt dodecyl sulfate acid has the following advantages in comparison with other surfactants: non-toxic (4th class); cheapness; the process requires a NaDS, the stoichiometry of chemical reactions; the NaDS in the wide ranges of pH of the liquid phase; possibility of regeneration of the products; compared with similar surfactant extract rare metals of sodium dodecyl sulfate are maximum values. The pilot objects of scientific research were fully explored using modern instrument base, original techniques and modern instrumental methods of analysis such as photometry, infrared spectroscopy, complexometric titration, potentiometry, conductivity. The scientific research ensured new data on termodinamics description of the adsorption-bubble process on the surface of the liquid-gas phase and results for effective recovery of rare earth metals with a composition of sublates.

Dr. Ponomareva Maria has completed her PhD at the age of 24 years from National mineral resources university. She is the assistant of the department of general and physical chemistry of National mineral resources university. She is engaged in research in the field of adsorption and ion exchange of rare and rare-earth metals from complex salt solutions. She has published more than 20 papers in scientific journals.

The adsorption of anionic complexes of erbium with Trilon B on D-403 anionite is studied at ionic strengths of 1 mol/kg (NaNO3) and temperatures of 298 and 343 K. D-403 anionite is Chinese-made weakly basic macroporous polystyrene chelate anionite. Before the experiment anionite was transfered to nitrate form. Sorption was studied from erbium nitrates standard solutions. Trilon B was added as complexing agent with mole ratio of 1:1 in accordance with the following reaction stoichiometry. Formation of complexes with composition was proven by conductometric and potentiometric titration of 10 ml aliquot erbium nitrate (3+) with concentration of 0.05 mol/l with Trilon B solution with concentration of 0.05 mol/l. Values of the stability constants of anionic complexes of Er3+ with Trilon B, plus the Gibbs energies of the complexation reaction is Kstability=2.32•1018; . A thermodynamic description of the sorption isotherm was created using a linear form of the law of mass action, modified for the ion exchange reaction. At a temperature of 298 K the total adsorption of anionite the total adsorption of anionite is Г∞=0.095±0.05 mol/kg, equilibrium constant K=42±2, and the Gibbs energy of ion exchange . At a temperature of 343 K the total adsorption of anionite is Г∞ = 0.15 ±0.05 mol/kg, equilibrium constant K=54±3, and the Gibbs energy of ion exchange.

Alena Kuzhaeva has completed her PhD from Herzen State Pedagogical University, Russia. She works in the National Mineral Resources University (Mining University) at the Department of General and Physical Chemistry. She has published more than 40 papers in reputed journals.

One of the methods of obtaining functionalized heterocycles is the 1,3-dipolar cycloaddition reaction involving nitroalkenes as dipolarophiles containing a trihalogenmethyl group at β-position in their structure. 1,3 - dipolar cycloaddition of phenylazide to 1 - nitro- and 1 - bromo - 1 - nitro - 3,3,3 - trifluoro(chlorine)propenes was carried out through the intermediate formation of regioisomeric triazolines, which under the reaction conditions underwent intramolecular transformation (denitration, dehydrogenation, dehydrohalogenation) culminating in the formation of the corresponding triazoles with or without nitro-group. The structure of obtained compounds is proved by modern physical-chemical research methods and the formation of these compounds does not contradict with reference data on such adducts obtaining in reaction of 1,3-dipolar cycloaddition with the same structure type nitroalkenes which contain CO2R and P(O)(OR)2 groups instead of the С(Hlg)3 substitute in their structure.

Kirill Karapetian is an Associate Professor in National Mineral Resources University, Russia.

Development of glassy phosphate fertilizers which dissolve at a predetermined rate for use in crop areas of high humidity. The monitoring of water status in the areas of active fertilizer use. Assessing the impact of traditional fertilizers and fertilizer new sort on the state of coastal rivers. In this paper the authors propose measures to improve the environmental conditions of water protection zones through the use of new types of phosphate fertilizers. The results obtained by the use of glassy fertilizers in intensive nature meet the requirements of European Union. The fertilizer is intended for restoration of territories of former coal quarries and mines.