Nawal Serradji
Paris Diderot University, France
Title: When iron chelation encounters bacterial inhibition
Biography
Biography: Nawal Serradji
Abstract
Chlamydia trachomatis, a strict intracellular Gram-negative bacterium, is responsible for the most common sexually transmitted bacterial infection in the world (350,000 people infected) and trachoma. This infection also facilitates the transmission of other STIs, HIV for instance. The costs resulting from the treatment of this genital infection, or its sequelae, have thus been estimated at hundreds of millions of dollars per year. In addition, the persistent forms of this bacterium can lead to secondary inflammatory diseases like atherosclerosis and arthritis. No vaccine is available in humans. The search for new tools against this family of bacteria is therefore essential. Our group proposes such a tool thanks to the discovery of a new compound more active than the parent molecule, in a model of acute infection. Moreover, this new molecule is not toxic in cellulo.