2^nd World Chemistry Conference

Biography

Biography: Tulio Chavez-Gil

Abstract

The fast emerging in antimicrobial resistance has been the timely challenge for all classes of antibiotics, temporarily assuaging the concerns of modern medicine. Nowadays, there has been a significant retraction on the drugs design and research investment to attain new antimicrobial medicines by the major pharmaceutical companies with the coinciding escalation in global nosocomial infection. Metallo-antibiotic compounds has been less related with medicine applications and here we are presenting new results about the antimicrobial activity of a series of chelators having N and O functionalities and its vanadium complexes as a lane of research developed with particular emphasis to test its antibiotic activity against the emergent so called “ESKAPE” super bugs. Some of the most serious infection caused by ESKAPE strains is bateremia, pneumonia, osteomyelitis, acute endocarditis, myocarditis, pericarditis, cerebritis, meningitis, chorioamnionitis, scalded skin syndrome, abscesses of the muscle, urogenital tract, central nervous system, and various intra abdominal organs. The proposed artificial antibiotics and its derived complexes has being synthesized between dipicolonic acid (found in bacteria’s cell wall), 2-methylsalycilate, anthranilic acid, and NH4VO3. Those nonlactamase chelators and its vanadium compounds, still acting as either cytotoxic or bacteriostatic agents against a broad scope of bacteria strains. The in vitro preliminary screening with Gram-(positive/negative) strains suggests powerful growth inhibition activity on different bacteria viz., Staphylococcus aureus; Staphylococcus epidermidis; Bacillus cereus; Streptococcus faecalis; Acinetobacter bawmannii; Citrobacter freundii; Salmonella typhimurium; Serratia marcenses; Escherichia coli; Enterobacter aerogenes; Enterobacter cloacae; Klebsiella pneumoniae; Pseudomonas aeruginosa, and Proteus vulgaris.