2^nd World Chemistry Conference

Biography

Biography: Thirumeni Subramanian

Abstract

A simple, green, clean and reusable method is developed for the synthesis of primary aromatic amines from aryl halides and arylboronic acids using aqueous ammonia and Cu(I)-Y zeolite as a heterogeneous catalyst. Using this very convenient, inexpensive, reusable and practical approach, a variety of substituted aryl halides and arylboronic acids are readily aminated. Amination processes find applications in the production of aminopyridines and pyrroles. Use of these homogeneous catalysts are generally connected with problems in separation, recovery and regeneration of the catalysts which can be minimised using a heterogeneously catalyzed reaction. Zeolites/clays are capable of stabilising small metal particles and can maintain their activity. In addition, zeolites are known for their shape selectivity, which can enhance the selectivity of the heterogeneous catalysis. This procedure outlined here is highly competitive with existing copper based catalysts and it can be readily adopted in custom synthesis and industrial processes. This coupling reaction involving ammonia was performed under nitrogen atmosphere at room temperature without the need for sealed reaction set-up, no external ligand to stabilize the metal ion, easy separation and avoids unwanted side reactions. This efficient copper catalyzed method is also successfully studied for the synthesis of primary aromatic amines by coupling of arylboronic acids. It is relevant to note here that in a recent review on catalytic organometallic reactions of ammonia, Hartwig has highlighted a few remaining goals to be accomplished in this vital area. The present work fulfils two of these challenges, namely lower temperature and reaction of ortho-substituted aryl halides. Further studies are underway to expand the scope of this method to other related synthetic applications.