Alireza Doroudi
Ahvaz Jundishapur University of Medical Sciences, Iran
Title: The application of ultrasound irradiation technique for the reconstitution of radiopharmaceutical kits
Biography
Biography: Alireza Doroudi
Abstract
Sonochemistry is a branch of chemical research dealing with the application of ultrasound waves. Green chemistry has successfully improved the yield of the reactions, changed the reaction pathway or initiated the reaction. Technetium 99m 2-methoxy isobutyl isonitrile is a lipophilic cation complex that has been accumulated in viable myocardial tissue by passive diffusion into myocyte with subsequent binding to the mitochondria within the cell. This radiotracer has been demonstrated suitable characteristics for myocardial perfusion studies. The freeze dried kit of sestamibi contains 2-methoxy isobutyl isonitirle (Sestamibi) as a performed copper (I) complex, which facilitates labeling by ligand exchange at elevated temperature. The labeling process of MIBI as a conventional method is time-consuming. It is highly desirable to reduce the time of labeling process particularly in emergency situations in clinical practice. In our previous study, 37 MBq(1mCi) 99mTc-MIBI samples with appropriate yields could be reconstituted under ultrasound irradiation technique. Then the activity was scaled up to the amounts that could be used for myocardial perfusion imaging. The new developed technique has been suggested for preparation of 99mTc-MIBI in clinical practice. We continued our achievement to the other radiopharmaceutical kit which the reconstitution is time-consuming in nuclear medicine departments.