Oladepo Mutiu Lolade
Adekunle Ajasin University, Nigeria
Title: Effect of saponin from Solanum anguivi on heart function of Alloxan induced Diabetic rats
Biography
Biography: Oladepo Mutiu Lolade
Abstract
Solanum anguivi is a semi-domestic indigenous vegetable very valuable in many African countries with potential to become a cultivated market vegetable in Nigeria. Uptake of Solanum anguivi cause hypoglycemic effect, hypertension etc. The effect of Saponin from Solanum anguivi on heart function of the alloxan-induced diabetic rat was investigated in this study. Twenty four (24) rats of average weight 120g were randomly divided into six (6) groups A-F. Group A (control) rats were given 2.0ml of distilled water, Group B (Diabetic control), Group C to F were diabetic rats which were administered 20mg/kg, 40mg/kg and 80mg/kg Saponin from Solanum anguivi respectively for 14 days. The results showed that there was a significant reduction in plasma glucose in the diabetic rat to almost the level in the control. The result also shows that there were a significant reduction in Aspartate Aminotransferase (AST) and Alanine aminotransferase (ALT) activities in serum and heart compared with the control (p<0.05). This study shows that Solanum anguivi fruit has an anti-diabetic effect on alloxan induced diabetic rat.