Ruimao Hua
Tsinghua University, China
Title: Syntheses of functional molecules via alkyne annulation
Biography
Biography: Ruimao Hua
Abstract
Transition metal-catalyzed annulation of alkynes with high atom-utilization and economic steps, is one of the most important methods for construction of carbocyclic and heterocyclic compounds. In the presence of rhodium, palladium, copper or other transition metal complexes, we have studied the annulation of alkynes to develop the efficient synthetic methods for multi-substituted indoles and human 5-selective serotonin 2A receptor (h5-HT2A) antagonist, the natural product skeleton of cassiarin C; multi-substituted chrysenes as well as the fused cyclic quinolines.