Maryam Sadat Hosseini Zare
Texas Southern University, USA
Title: A novel copper-catalyzed C-C bond cleavage of aryl (Heteroaryl) alkyl ketones for C-N bond formation
Biography
Biography: Maryam Sadat Hosseini Zare
Abstract
Double layered one-by-one imprinted hollow core-shells@ pencil graphite electrode was fabricated for sequential sensing of anti-HIV drugs. For this, two eccentric layers were developed on the surface of vinylated silica nanospheres to obtain double layered one-by-one imprinted solid core-shells, which on treatment with hydrofluoric acid yielded hollow core-shells. Whereas modified hollow core-shells (single layered dual imprinted) evolved competitive diffusion of probe/analyte molecules, the corresponding double layered one-by-one imprinted hollow core-shells (outer layer imprinted with Zidovudine, and inner layer with Lamivudine) were found relatively better owing to their bilateral diffusions into molecular cavities without any competition. Therefore, entire work in this article is based on differential pulse anodic stripping voltammetry at double layered one-by-one imprinted hollow core-shells, which imparted indirect detection of electro inactive targets with limits of detection as low as 0.91 and 0.12 (aqueous sample), 0.94 and 0.13 (blood serum), and 0.99 and 0.20 ng mL-1 (pharmaceutics) for lamivudine and zidovudine, respectively in anti-HIV drug combination.