Meet Inspiring Speakers and Experts at our 3000+ Global Conference Series Events with over 1000+ Conferences, 1000+ Symposiums
and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.

Explore and learn more about Conference Series : World's leading Event Organizer

Back

Ganapathy Sivakumar

Ganapathy Sivakumar

University of Houston, USA

Title: Biomanufacturing of Biorhizome-based Colchicine

Biography

Biography: Ganapathy Sivakumar

Abstract

Many human medicines are biomanufactured by recombinant DNA technology. Colchicine is one of the potential plant-based alkaloid medicines used to treat gout, which is commercially extracted from Gloriosa superba. My laboratory is establishing the biorhizome-based colchicine biomanufacturing technology to produce the drugs. G. superba-based biorhizomes are unique and efficient colchicine biosynthetic mechanisms, which is an advanced biotechnological platform compared to root and cell cultures. 

Colchicine from biorhizomes could lower upstream biomanufacturing costs, speed production and reduce pesticide contamination.  Metabolic engineering of colchicine biosynthetic pathway in biorhizome requires detailed pathway elucidation. The biorhizome-based colchicine biomanufacturing and colchicine pathway elucidation will be presented.