Elias Baydoun
American University of Beirut, Lebanon
Title: Fungal-mediated structural transformation of contraceptive drugs, drospirenone and etonogestrel into new metabolites
Biography
Biography: Elias Baydoun
Abstract
Biotransformation is an efficient approach for structural alteration of all classes of organic compounds. This technique is effectively employed in green chemistry, particularly in drug discovery and development, as it involves a variety of enzymes during transformation which results in regio-, chemo-, and stereo-selective products. In the current study, biotransformation of an orally active contraceptive drugs, drospirenone and etonogestrel was carried out at pH 7.0 and 26±2°C. Transformation of drospirenone with Cunninghamella elegans resulted in four new metabolites, 14α-hydroxy-drospirenone, 11-oxo-drospirenone, 12-oxo-drospirenone and 11β, 14α-dihydroxy-drospirenone, along with a known metabolite and 11α-hydroxy-drospirenone. While transformation of etonogestrel with Cunninghamella blakesleeana and C. echinulata yielded three new metabolites 6β-hydroxy-11, 22-epoxy-etonogestrel, 11, 22-epoxy-etonogestrel, 10β-hydroxy-etonogestrel, along with two known metabolites 6β-hydroxy-etonogestrel, and 14α-hydroxy-etonogestrel.