Drug Discovery and Development
Drug discovery is a process which is intended to identify a small synthetic molecule or a large biomolecule for comprehensive evaluation as a potential drug candidate. Broadly, the modern drug discovery process includes identification of disease to be treated and its unmet medical need, selection of a druggable molecular target and its validation, in vitro assay development followed by high throughput screening of compound libraries against the target to identify hits, and hit optimization to generate lead compounds that exhibit adequate potency and selectivity towards the biological target in vitro and which demonstrate efficacy in animal models of disease. Subsequently, the lead compounds are further optimized to improve their efficacy and pharmacokinetics before they advance towards drug development.
Drug development process can be segregated into preclinical and clinical development stages. In preclinical development, toxicological and safety pharmacology studies of the candidate are conducted in order to establish the maximum safe concentrations in animals and determine the adverse effect potential of the drug-in-development. Additionally, studies are conducted to finalize cost-effective processes required for manufacturing the candidate drug as well as deciding on its best formulation. If the candidate exhibits sufficient efficacy and safety in preclinical evaluation, permission is sought from drug regulatory agencies to initiate its clinical development wherein the safety and efficacy of the drug candidate is assessed in pilot and pivotal studies.
- Computational approaches in drug discovery and precision medicine
- Phosphonate chemistry in drug design and development
- In silico methods for drug design and discovery
- Neglected Diseases: Chagas Disease, Human African Trypanosomiasis, and Leishmaniasis
- Anti-Tubercular drugs
- Computational drug discovery for targeting of protein-protein interfaces
- Multi-target-directed ligands (MTDL) in drug discovery: from design to pharmacological evaluation
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- Personalized Medicine and Biomarker-Driven Approaches in Neurodegenerative Diseases - Vascular Dementia Congress 2025 (Switzerland)
- Personalized Sleep Therapies - SLEEP DISORDER 2025 (Netherlands)
- Pharmacological Advances in Dementia Treatment - Euro Dementia 2025 (Germany)
- Pioneering Techniques in Awake Craniotomy - Neuro Surgery 2025 (UK)
- Precision Medicine and Genomics in Spinal Disorders - Spine 2025 (Italy)
- Protein Misfolding and Aggregation in Neurodegenerative Disorders - Vascular Dementia Congress 2025 (Switzerland)
- Psychiatric Comorbidities in Neurological Disorders - Neurology Congress 2025 (UK)
- Psychiatric Disorders - Neuroscience 2025 (France)
- Psychiatric neuroscience - Neuroscience Congress-2025 (France)
- Psychiatry - Mental Health Congress 2025 (France)
- Psychiatry and Psychology - Neurogenetics 2025 (Canada)
- Psychiatry Mental Health Disorders - Dementia-2025 (Switzerland)
- Psychological Research - Mental Health Congress 2025 (France)
- Psychotherapy and Counselling - Mental Health Congress 2025 (France)
- Public Health Initiatives and Advocacy - Alzheimers-2025 (France)
- Rapid Sleep Diagnostics - SLEEP DISORDER 2025 (Netherlands)
- Rare Neurological Disorders and Case Studies - Neurological Disorders 2025 (Netherlands)
- Recent Studies & Case Reports - Dementia-2025 (Switzerland)
- Regenerative Medicine and Stem Cell Therapy for Spinal Disorders - Spine 2025 (Italy)
- Rehabilitation and Neuroplasticity - NEUROSCIENCE_2025 (France)
- Rehabilitation and Restorative Therapy in Stroke - Stroke Summit 2025 (Canada)
- Risk factor and Prevention of Stroke - Stroke Summit 2025 (Canada)
- Risk factors, Diagnosis, Medications, and Recovery - Stroke Meeting 2025 (France)
- Robotic Neurosurgery - Neuroscience Congress 2025 (Canada)
- Robotic Neurosurgery - CNS 2025 (Germany)
- Role of Inflammation and Oxidative Stress in Vascular Dementia - Vascular Dementia Congress 2025 (Switzerland)
- Schizophrenia - Neuroscience Congress-2025 (France)
- Screen Time Effects - SLEEP DISORDER 2025 (Netherlands)
- Shift Worker Sleep Tips - SLEEP DISORDER 2025 (Netherlands)
- Skull Base Surgery: Techniques and Outcomes - Neuro Surgery 2025 (UK)
- Sleep Apnea Device Overview - SLEEP DISORDER 2025 (Netherlands)
- Sleep disorder - Mental Health Congress 2025 (France)
- Sleep Disorders - BRAIN DISORDER - 2025 (France)
- Sleep Disorders and Circadian Neuroscience - NEUROSCIENCE_2025 (France)
- Sleep Disorders and Their Neurological Implications - Neurology Congress 2025 (UK)
- Sleep Disorders: Pathophysiology and Management - Neurological Disorders 2025 (Netherlands)
- Sleep Hygiene Essentials - SLEEP DISORDER 2025 (Netherlands)
- Sleep in Mental Health - SLEEP DISORDER 2025 (Netherlands)
- Sleep Myths vs. Facts - SLEEP DISORDER 2025 (Netherlands)
- Spinal Biomechanics and Kinesiology - Spine 2025 (Italy)
- Spinal Cord Injuries: Innovations and Rehabilitation - Neurological Disorders 2025 (Netherlands)
- Spinal Cord Injuries: Surgical Management and Rehabilitation - Neuro Surgery 2025 (UK)
- Spinal Cord Injury: Advances in Treatment and Regeneration - Neurology Congress 2025 (UK)
- Spinal Deformities: Diagnosis and Treatment Innovations - Spine 2025 (Italy)
- Spinal Disorders and Spine Surgery - CNS 2025 (Germany)
- Spinal Tumors: Diagnosis, Treatment, and Outcomes - Spine 2025 (Italy)
- Spine and Spinal disorders - Neuroscience Congress 2025 (Canada)
- Spine Disorders in the Aging Population: Challenges and Solutions - Spine 2025 (Italy)
- Sports-Related Spinal Injuries: Diagnosis, Prevention, and Treatment - Spine 2025 (Italy)
- Sports-Related Spine Injuries and Rehabilitation - Spine 2025 (Italy)
- Stem Cell Therapy and Regenerative Medicine in Neurosurgery - Neuro Surgery 2025 (UK)
- Stem Cells & Brain Repair - Neuroscience 2025 (France)
- Stigma and Mental Health - EURO MENTAL DISORDER 2025 (France)
- Stress and Sleep Connection - SLEEP DISORDER 2025 (Netherlands)
- Stroke - Stroke Summit 2025 (Canada)
- Stroke & Neurological Disorders - Neuroscience 2025 (France)
- Stroke and Cerebrovascular Diseases - Stroke Meeting 2025 (France)
- Stroke and Cerebrovascular Disorders - BRAIN DISORDER - 2025 (France)
- Stroke and Cerebrovascular Disorders - NEUROSCIENCE_2025 (France)
- Stroke and Neurological Disorders - Neuroscience Congress 2025 (Canada)
- Stroke and Post-Stroke Dementia: Prevention and Management - Vascular Dementia Congress 2025 (Switzerland)
- Stroke and recovery - Neuroscience Congress-2025 (France)
- Stroke Management and Cerebrovascular Disorders - Neurological Disorders 2025 (Netherlands)
- Stroke Rehabilitation and Brain Hemorrhage - Stroke Meeting 2025 (France)
- Stroke risk, phenotypes, and death in COVID-19 - Stroke Meeting 2025 (France)
- Substance Abuse and Mental Health - EURO MENTAL DISORDER 2025 (France)
- Suicide Prevention Strategies - EURO MENTAL DISORDER 2025 (France)
- Targeting Neurovascular Dysfunction in Neurodegenerative Diseases - Vascular Dementia Congress 2025 (Switzerland)
- Tauopathies and Synucleinopathies: Molecular Mechanisms of Neurodegeneration - Vascular Dementia Congress 2025 (Switzerland)
- Technological Innovations in Mental Health - EURO MENTAL DISORDER 2025 (France)
- The Future of Neurodegenerative Disease Therapy: Stem Cells and Regenerative Medicine - Vascular Dementia Congress 2025 (Switzerland)
- The Future of Spinal Robotics and Smart Wearable Technologies - Spine 2025 (Italy)
- The Impact of Epilepsy on Cognitive Function and Quality of Life - Epilepsy 2025 (Spain)
- The Impact of Epilepsy on Cognitive Function and Quality of Life - Epilepsy 2025 (Spain)
- The Impact of Space Travel and Microgravity on the Spine - Spine 2025 (Italy)
- The Intersection of Mental Health and Chronic Spine Disorders - Spine 2025 (Italy)
- The Role of Neurostimulation in Epilepsy Management - Epilepsy 2025 (Spain)
- The Role of Neurostimulation in Epilepsy Management - Epilepsy 2025 (Spain)
- The Role of Nutrition and Lifestyle in Spinal Health - Spine 2025 (Italy)
- The Role of Seizure Monitoring and Technology in Epilepsy Management - Epilepsy 2025 (Spain)
- Traumatic brain injury - Neuroscience Congress-2025 (France)
- Traumatic Brain Injury - Brain Disorders-2025 (USA)
- Traumatic Brain Injury (TBI) and Neurotrauma - Neuro Surgery 2025 (UK)
- Vascular Dementia - Euro Dementia 2025 (Germany)
- Women's Mental Health - EURO MENTAL DISORDER 2025 (France)
- Women’s Sleep Health - SLEEP DISORDER 2025 (Netherlands)
- Workplace Mental Health - EURO MENTAL DISORDER 2025 (France)