Day 1 :
Keynote Forum
Claire Mangeney
University Paris Diderot, France
Keynote: Hybrid Nanostructures made of Gold Nanoparticles and Functional Polymers: Chemistry and Applications in Sensors
Time : 09:20-09:50
Biography:
Claire Mangeney is full professor at the LCBPT Laboratory of University Paris Descartes. Her research is at the interface of surface chemistry, nanotechnology and biology. She has developed over the last decade original chemical strategies to attach polymers (brushes, imprinted and smart polymers, hydrogels) on planar and micro/nano-structured surfaces from diazonium salts as a new generation of coupling agents. Her primary goal is to develop hybrid nanomaterials for biological and energy-related applications.
Abstract:
Gold nanoparticles have stimulated a wide range of interest these past years due to their remarkable optical, electronic, and catalytic properties. Generally, the use of these nanoparticles requires their functionalization or combination with functional molecules, the nature of which depends on the target application. In this talk, we present the design of hybrid plasmonic nanostructures, made of regular arrays of gold nanoparticles, coated by ultra-thin layers of functional polymers (smart, reactive and molecularly imprined polymers). We have studied the sensitivity of these plasmonic nanostructures to variations in properties of the local environment (temperature, refractive index, polymer thickness), in the context of sensing and active lasmonic applications. The grafting of the polymer on the gold nanostructures results from a multistep but simple approach in order to confine the polymer layers on the gold nanoparticles and to control the thickness of the polymer coating. Moreover, the coupling between gold nanostructures and molecularly imprinted polymer shells provide optical nanosensors enabling the direct, label-free detection of various kinds of molecules, such as folic acid and paracetamol. We do believe this synthetic approach provides a new general nanomaterial strategy design for the grafting of functional polymers on gold nanoparticles. This work could therefore provide an important step toward the use of hybrid structures for applications spanning from opto-mechanical modulators to nanoscale adhesion and molecular sensing.
Keynote Forum
Eric Pasquinet
CEA, France
Keynote: A Staudinger-diaza-wittig tandem reaction and its application to the synthesis of 1H-indazoles, 1H-benzoindazoles and 1H-azaindazoles from (het)aryl azides
Time : 09:50-10:20
Biography:
Eric Pasquinet has completed his PhD from the University of Rouen. He has been working for more than 15 years at CEA on synthesis projects, mainly involving nitrogen heterocycles. He has published more than 25 papers and 12 patents.
Abstract:
The aza-Wittig reaction is a widely known and used reaction, which consists of the coupling between an iminophosphorane (obtained from the reaction of a trialkylphosphine on an azide) and an unsaturated carbonyl-type compound. In its intramolecular version, the aza-Wittig reaction gives access to many aza-heterocycles from 5- to 7-membered rings. In such processes, the use of N-electrophiles has never been reported. We investigated nitroso compounds as electrophiles to promote the formation of a N=N double bond. In particular, we found that minophosphoranes (coming from the reaction between an aromatic azide and a trialkylphosphine) could cyclize onto an ortho benzylic nitroso moiety, leading to a 3H-indazole that isomerized into its more stable 1H analogue. This process can be operated one-pot, without isolation of the intermediate iminophosphorane. This means that, in a single operation starting from an aromatic azide, the targeted 1H-indazole is generated. Various aryl- and hetaryl azides were used to demonstrate the generality of the method, leading to 1H-indazoles, 1H-benzoindazoles and 1H-azaindazoles. The reaction pathway will also be discussed. It involves a mechanism analogous to that reported for the aza-Wittig reaction. Therefore the key transformation of the process was given the name ‘diaza-Wittig’.
- Physical Chemistry
Environmental Chemistry
Theoretical Chemistry
Location: Linate
Chair
Goncagul Serdaroglu
Cumhuriyet University, Turkey
Co-Chair
Dorothee ARNS
Petrochemicals Europe, Belgium